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Medientyp:
E-Artikel
Titel:
EFFECTS OF L-ASCORBIC ACID AND ALPHA-TOCOPHEROL ON BIOCHEMICAL PARAMETERS OF SWIMMING-INDUCED OXIDATIVE STRESS IN SERUM OF GUINEA PIGS
Beteiligte:
Bursać-Mitrović, Marija;
Milovanović, Dragan R.;
Mitić, Radoslav;
Jovanović, Danijela;
Sovrlić, Miroslav M.;
Vasiljević, Perica;
Tomović, Jovica;
Manojlović, Nedeljko
Erschienen:
African Traditional Herbal Medicine Supporters Initiative (ATHMSI), 2016
Erschienen in:
African Journal of Traditional, Complementary and Alternative Medicines, 13 (2016) 4, Seite 29-33
Sprache:
Nicht zu entscheiden
DOI:
10.21010/ajtcam.v13i4.5
ISSN:
0189-6016;
2505-0044
Entstehung:
Anmerkungen:
Beschreibung:
Background: The purpose of this study is to determine the effect of L-ascorbic acid and alpha-tocopherol as well as combination of
these vitamins with or without exposure to physical exercise on intensity of lipid peroxidation, activity of xanthine oxidase, activity
of total antioxidative system, concentration of glutathione, and activity of catalase in the serum of guinea pigs.
Materials and Methods: The experimental measurements of intensity of lipid peroxidation, activity of xanthine oxidase, activity of
total antioxidative system, concentration of glutathione, and activity of catalase were done in the serum of guinea pigs. The animals
were exposed to the test load to achieve exhaustion and the test was terminated when the animal for the third time to sink into the
water.
Results: The results of this study demonstrated that endurance exercise of guinea pigs induced oxidative stress response in terms of
increased lipid peroxidation and activity of xanthine oxidase in the serum of experimental animals. Our study investigated the
antioxidant activity of L-ascorbic acid and alpha-tocopherol also measuring three protective markers in the serum: total antioxidant
activity, content of glutathione and activity of catalase. The results obtained show that the vitamins influence the concentrations of
above mentioned biochemical parameters, which points out their protective effect of swimming-induced oxidative stress.
Conclusion: Single or combined administration of L-ascorbic acid and alpha-tocopherol caused significant inhibition of these
markers indicating the important antioxidant activity of the vitamins. Results lead to conclude that the combined treatments with
vitamins with or without exposure to physical exercise showed the clear synergistic effect.