Beschreibung:
<jats:p>Introduction: Infection with Clostridium difficile (CDI) is the most frequent
cause of nosocomial diarrhoeas. Most cases are successfully treated by
antibiotic therapy, but nearly 10% may progress to the fulminative form of
this condition. The objective of the work is retrospective evaluation of the
results of surgical treatment in patients with the fulminative form of
Clostridium colitis with revealing of risk factors leading to serious
post-operative morbidity and mortality. Patients and methodology:
Retrospective evaluation of the results of surgical treatment in patients
with the fulminative form of Clostridium colitis between 2008 and 4/2012.
Results: Between 2008 and 4/2012 Clostridium toxins were positively detected
in 1,088 patients in total, 21 of whom underwent operations due to the
fulminative form of Clostridium colitis. The operations included 4 total
colectomies with terminal ileostomy, 15 subtotal colectomies with terminal
ileostomy, 1 caecostomy and 1 axial ileostomy. The 30-day mortality was
23.8%, and morbidity reached 66.6%. High leukocytosis is a statistically
significant predictor of post-operative mortality and morbidity (p= 0.008).
Conclusion: Early indication for a colectomy operation with terminal
ileostomy in patients with the fulminative form of Clostridium colitis leads
to lower morbidity and mortality.</jats:p>