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Medientyp:
E-Artikel
Titel:
Insight into hepatocellular carcinoma biology with gadoxetate disodium-enhanced MRI
Beteiligte:
Kagen, Alexander;
Fowler, Kathryn;
Sirlin, Claude B
Erschienen:
Informa UK Limited, 2014
Erschienen in:
Hepatic Oncology, 1 (2014) 1, Seite 95-105
Sprache:
Englisch
DOI:
10.2217/hep.13.11
ISSN:
2045-0923;
2045-0931
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p> SUMMARY The current algorithm for the imaging diagnosis of hepatocellular carcinoma accurately detects large, progressed tumors displaying the classical imaging features of arterial hyperenhancement with ‘washout’ and/or ‘capsule’ appearance. Liver MRI with the relatively newer hepatobiliary agent, gadoxetate disodium, provides information on hepatocellular function in addition to vascularity, facilitates detection of small progressed tumors, as well as early/vaguely nodular tumors, and shows promise for characterizing hepatocellular carcinoma biology. Prediction of tumor grade, presence of biliary and stem cell markers, microvascular invasion, future hypervascularization and post-treatment recurrence have all been studied with gadoxetate disodium-enhanced MRI with encouraging results. Incorporation of gadoxetate disodium-enhanced MRI into standard diagnostic and management algorithms will likely unfold in the future. </jats:p>