Beschreibung:
<jats:sec><jats:title>Background:</jats:title><jats:p>Multinucleate cell angiohistiocytoma is a rare benign fibrohistiocytic and vascular proliferation, typically characterized by the development of solitary papules, in an acral distribution in otherwise healthy late middle-aged to elderly women.</jats:p></jats:sec><jats:sec><jats:title>Objective:</jats:title><jats:p>Our objectives are to present a novel case of generalized multinucleate cell angiohistiocytoma and to review the current literature regarding the clinical and histologic findings in this condition, as well as its potential causes and treatments.</jats:p></jats:sec><jats:sec><jats:title>Observations:</jats:title><jats:p>We describe a 35-year-old man who presented with generalized asymptomatic firm violaceous papules. Histopathology revealed dermal vascular proliferation; a perivascular infiltrate of lymphocytes, histiocytes, neutrophils, and plasma cells; thickened surrounding collagen bundles; and characteristic multinucleate cells with scalloped borders.</jats:p></jats:sec><jats:sec><jats:title>Conclusion:</jats:title><jats:p>Our patient is one of three patients reported to date with generalized lesions of multinucleate cell angiohistiocytoma who were all in a younger age group (20–40 years old) than previously reported for solitary lesions.</jats:p></jats:sec>