> Detailanzeige

Forbes, Josephine M.; McCarthy, Domenica A.; Kassianos, Andrew J.; Baskerville, Tracey; Fotheringham, Amelia K.; Giuliani, Kurt T.K.; Grivei, Anca; Murphy, Andrew J.; Flynn, Michelle C.; Sullivan, Mitchell A.; Chandrashekar, Preeti; Whiddett, Rani; Radford, Kristen J.; Flemming, Nicole; Beard, Sam S.; D’Silva, Neisha; Nisbet, Janelle; Morton, Adam; Teasdale, Stephanie; Russell, Anthony; Isbel, Nicole; Jones, Timothy; Couper, Jennifer; Healy, Helen; [...]

T-Cell Expression and Release of Kidney Injury Molecule-1 in Response to Glucose Variations Initiates Kidney Injury in Early Diabetes

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: T-Cell Expression and Release of Kidney Injury Molecule-1 in Response to Glucose Variations Initiates Kidney Injury in Early Diabetes
  • Beteiligte: Forbes, Josephine M.; McCarthy, Domenica A.; Kassianos, Andrew J.; Baskerville, Tracey; Fotheringham, Amelia K.; Giuliani, Kurt T.K.; Grivei, Anca; Murphy, Andrew J.; Flynn, Michelle C.; Sullivan, Mitchell A.; Chandrashekar, Preeti; Whiddett, Rani; Radford, Kristen J.; Flemming, Nicole; Beard, Sam S.; D’Silva, Neisha; Nisbet, Janelle; Morton, Adam; Teasdale, Stephanie; Russell, Anthony; Isbel, Nicole; Jones, Timothy; Couper, Jennifer; Healy, Helen; [...]
  • Erschienen: American Diabetes Association, 2021
  • Erschienen in: Diabetes, 70 (2021) 8, Seite 1754-1766
  • Sprache: Englisch
  • DOI: 10.2337/db20-1081
  • ISSN: 0012-1797; 1939-327X
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Half of the mortality in diabetes is seen in individuals <50 years of age and commonly predicted by the early onset of diabetic kidney disease (DKD). In type 1 diabetes, increased urinary albumin-to-creatinine ratio (uACR) during adolescence defines this risk, but the pathological factors responsible remain unknown. We postulated that early in diabetes, glucose variations contribute to kidney injury molecule-1 (KIM-1) release from circulating T cells, elevating uACR and DKD risk. DKD risk was assigned in youth with type 1 diabetes (n = 100; 20.0 ± 2.8 years; males/females, 54:46; HbA1c 66.1 [12.3] mmol/mol; diabetes duration 10.7 ± 5.2 years; and BMI 24.5 [5.3] kg/m2) and 10-year historical uACR, HbA1c, and random blood glucose concentrations collected retrospectively. Glucose fluctuations in the absence of diabetes were also compared with streptozotocin diabetes in apolipoprotein E−/− mice. Kidney biopsies were used to examine infiltration of KIM-1–expressing T cells in DKD and compared with other chronic kidney disease. Individuals at high risk for DKD had persistent elevations in uACR defined by area under the curve (AUC; uACRAUC0–10yrs, 29.7 ± 8.8 vs. 4.5 ± 0.5; P < 0.01 vs. low risk) and early kidney dysfunction, including ∼8.3 mL/min/1.73 m2 higher estimated glomerular filtration rates (modified Schwartz equation; Padj < 0.031 vs. low risk) and plasma KIM-1 concentrations (∼15% higher vs. low risk; P < 0.034). High-risk individuals had greater glycemic variability and increased peripheral blood T-cell KIM-1 expression, particularly on CD8+ T cells. These findings were confirmed in a murine model of glycemic variability both in the presence and absence of diabetes. KIM-1+ T cells were also infiltrating kidney biopsies from individuals with DKD. Healthy primary human proximal tubule epithelial cells exposed to plasma from high-risk youth with diabetes showed elevated collagen IV and sodium–glucose cotransporter 2 expression, alleviated with KIM-1 blockade. Taken together, these studies suggest that glycemic variations confer risk for DKD in diabetes via increased CD8+ T-cell production of KIM-1.
  • Zugangsstatus: Freier Zugang