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Brooks-Worrell, Barbara;
Hampe, Christiane S.;
Hattery, Erica G.;
Palomino, Brenda;
Zangeneh, Sahar Z.;
Utzschneider, Kristina;
Kahn, Steven E.;
Larkin, Mary E.;
Johnson, Mary L.;
Mather, Kieren J.;
Younes, Naji;
Rasouli, Neda;
Desouza, Cyrus;
Cohen, Robert M.;
Park, Jean Y.;
Florez, Hermes J.;
Valencia, Willy Marcos;
Shojaie, Ali;
Palmer, Jerry P.;
Balasubramanyam, Ashok;
Crandall, Jill P.;
McKee, Melissa Diane;
Brown-Friday, Janet;
Xhori, Entila;
[...]
Islet Autoimmunity Is Highly Prevalent and Associated With Diminished β-Cell Function in Patients With Type 2 Diabetes in the GRADE Study
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- Medientyp: E-Artikel
- Titel: Islet Autoimmunity Is Highly Prevalent and Associated With Diminished β-Cell Function in Patients With Type 2 Diabetes in the GRADE Study
- Beteiligte: Brooks-Worrell, Barbara; Hampe, Christiane S.; Hattery, Erica G.; Palomino, Brenda; Zangeneh, Sahar Z.; Utzschneider, Kristina; Kahn, Steven E.; Larkin, Mary E.; Johnson, Mary L.; Mather, Kieren J.; Younes, Naji; Rasouli, Neda; Desouza, Cyrus; Cohen, Robert M.; Park, Jean Y.; Florez, Hermes J.; Valencia, Willy Marcos; Shojaie, Ali; Palmer, Jerry P.; Balasubramanyam, Ashok; Crandall, Jill P.; McKee, Melissa Diane; Brown-Friday, Janet; Xhori, Entila; [...]
- Erschienen: American Diabetes Association, 2022
- Erschienen in: Diabetes
- Sprache: Englisch
- DOI: 10.2337/db21-0590
- ISSN: 0012-1797
- Entstehung:
- Anmerkungen:
- Beschreibung: <jats:p>Islet autoimmunity may contribute to β-cell dysfunction in type 2 diabetes (T2D). Its prevalence and clinical significance have not been rigorously determined. In this ancillary study to the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE), we investigated the prevalence of cellular and humoral islet autoimmunity in patients with T2D duration of 4.0 ± 3.0 years (HbA1c 7.5 ± 0.5% on metformin alone). We measured T-cell autoreactivity against islet proteins, islet autoantibodies against 65-kDa GAD antigen, IA-2, and zinc transporter-8, and β-cell function. Cellular islet autoimmunity was present in 41.3%, humoral islet autoimmunity in 13.5%, and both in 5.3%. β-Cell function calculated as incremental area under the curve of glucose from 0–120 min (iAUC-CG) and ΔC-peptide(0–30)/Δglucose(0–30) from an oral glucose tolerance test was lower among T-cell–positive (T+) than T-cell–negative (T−) individuals using two different adjustments for insulin sensitivity (iAUC-CG: 13.2% [95% CI 0.3, 24.4] or 11.4% [95% CI 0.4, 21.2] lower; ΔC-peptide[0–30]/Δglucose[0–30]: 19% [95% CI 3.1, 32.3] or 17.7% [95% CI 2.6, 30.5%] lower). T+ patients had 17% higher HbA1c (95% CI 0.07, 0.28) and 7.7 mg/dL higher fasting plasma glucose levels (95% CI 0.2, 15.3) than T− patients. We conclude that islet autoimmunity is much more prevalent in patients with T2D than previously reported. T-cell–mediated autoimmunity is associated with diminished β-cell function and worse glycemic control.</jats:p>
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