> Detailanzeige
Rossing, Peter;
Anker, Stefan D.;
Filippatos, Gerasimos;
Pitt, Bertram;
Ruilope, Luis M.;
Birkenfeld, Andreas L.;
McGill, Janet B.;
Rosas, Sylvia E.;
Joseph, Amer;
Gebel, Martin;
Roberts, Luke;
Scheerer, Markus F.;
Bakris, George L.;
Agarwal, Rajiv;
Aizenberg, Diego;
Bartolacci, Inés;
Besada, Diego;
Bittar, Julio;
Chahin, Mariano;
Elbert, Alicia;
Gelersztein, Elizabeth;
Liberman, Alberto;
Maffei, Laura;
Pérez Manghi, Federico;
[...]
Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes by Sodium–Glucose Cotransporter 2 Inhibitor Treatment: The FIDELITY Analysis
Teilen
Literatur-
verwaltung
Direktlink
Zur
Merkliste
Lösche von
Merkliste
Per Email teilen
Auf Twitter teilen
Auf Facebook teilen
Per Whatsapp teilen
- Medientyp: E-Artikel
- Titel: Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes by Sodium–Glucose Cotransporter 2 Inhibitor Treatment: The FIDELITY Analysis
- Beteiligte: Rossing, Peter; Anker, Stefan D.; Filippatos, Gerasimos; Pitt, Bertram; Ruilope, Luis M.; Birkenfeld, Andreas L.; McGill, Janet B.; Rosas, Sylvia E.; Joseph, Amer; Gebel, Martin; Roberts, Luke; Scheerer, Markus F.; Bakris, George L.; Agarwal, Rajiv; Aizenberg, Diego; Bartolacci, Inés; Besada, Diego; Bittar, Julio; Chahin, Mariano; Elbert, Alicia; Gelersztein, Elizabeth; Liberman, Alberto; Maffei, Laura; Pérez Manghi, Federico; [...]
-
Erschienen:
American Diabetes Association, 2022
- Erschienen in: Diabetes Care, 45 (2022) 12, Seite 2991-2998
- Sprache: Englisch
- DOI: 10.2337/dc22-0294
- ISSN: 0149-5992; 1935-5548
- Entstehung:
- Anmerkungen:
- Beschreibung: OBJECTIVE Finerenone reduced the risk of kidney and cardiovascular events in people with chronic kidney disease (CKD) and type 2 diabetes in the FIDELIO-DKD and FIGARO-DKD phase 3 studies. Effects of finerenone on outcomes in patients taking sodium–glucose cotransporter 2 inhibitors (SGLT2is) were evaluated in a prespecified pooled analysis of these studies. RESEARCH DESIGN AND METHODS Patients with type 2 diabetes and urine albumin-to-creatinine ratio (UACR) ≥30 to ≤5,000 mg/g and estimated glomerular filtration rate (eGFR) ≥25 mL/min/1.73 m2 were randomly assigned to finerenone or placebo; SGLT2is were permitted at any time. Outcomes included cardiovascular composite (cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure) and kidney composite (kidney failure, sustained ≥57% eGFR decline, or renal death) end points, changes in UACR and eGFR, and safety outcomes. RESULTS Among 13,026 patients, 877 (6.7%) received an SGLT2i at baseline and 1,113 (8.5%) initiated one during the trial. For the cardiovascular composite, the hazard ratios (HRs) were 0.87 (95% CI 0.79–0.96) without SGLT2i and 0.67 (95% CI 0.42–1.07) with SGLT2i. For the kidney composite, the HRs were 0.80 (95% CI 0.69–0.92) without SGLT2i and 0.42 (95% CI 0.16–1.08) with SGLT2i. Baseline SGLT2i use did not affect risk reduction for the cardiovascular or kidney composites with finerenone (Pinteraction = 0.46 and 0.29, respectively); neither did SGLT2i use concomitant with study treatment. CONCLUSIONS Benefits of finerenone compared with placebo on cardiorenal outcomes in patients with CKD and type 2 diabetes were observed irrespective of SGLT2i use.
- Zugangsstatus: Freier Zugang