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Thorsen, Steffen U.; Liu, Xiang; Kataria, Yachana; Mandrup-Poulsen, Thomas; Kaur, Simranjeet; Uusitalo, Ulla; Virtanen, Suvi M.; Norris, Jill M.; Rewers, Marian; Hagopian, William; Yang, Jimin; She, Jin-Xiong; Akolkar, Beena; Rich, Stephen; Aronsson, Carin Andrén; Lernmark, Åke; Ziegler, Anette-Gabriele; Toppari, Jorma; Krischer, Jeffrey; Parikh, Hemang M.; Ellervik, Christina; Svensson, Jannet; Rewers, Marian; Barbour, Aaron; [...]

Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study

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  • Medientyp: E-Artikel
  • Titel: Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study
  • Beteiligte: Thorsen, Steffen U.; Liu, Xiang; Kataria, Yachana; Mandrup-Poulsen, Thomas; Kaur, Simranjeet; Uusitalo, Ulla; Virtanen, Suvi M.; Norris, Jill M.; Rewers, Marian; Hagopian, William; Yang, Jimin; She, Jin-Xiong; Akolkar, Beena; Rich, Stephen; Aronsson, Carin Andrén; Lernmark, Åke; Ziegler, Anette-Gabriele; Toppari, Jorma; Krischer, Jeffrey; Parikh, Hemang M.; Ellervik, Christina; Svensson, Jannet; Rewers, Marian; Barbour, Aaron; [...]
  • Erschienen: American Diabetes Association, 2023
  • Erschienen in: Diabetes Care
  • Sprache: Englisch
  • DOI: 10.2337/dc22-1359
  • ISSN: 0149-5992; 1935-5548
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:sec> <jats:title>OBJECTIVE</jats:title> <jats:p>To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D).</jats:p> </jats:sec> <jats:sec> <jats:title>RESEARCH DESIGN AND METHODS</jats:title> <jats:p>In The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D. Exposures included energy-adjusted iron intake in the first 3 years of life and a genetic risk score (GRS) for increased circulating iron.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>We found a U-shaped association between iron intake and risk of GAD antibody as the first autoantibody. In children with GRS ≥2 iron risk alleles, high iron intake was associated with an increased risk of IA, with insulin as first autoantibody (adjusted hazard ratio 1.71 [95% CI 1.14; 2.58]) compared with moderate iron intake.</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS</jats:title> <jats:p>Iron intake may alter the risk of IA in children with high-risk HLA haplogenotypes.</jats:p> </jats:sec>
  • Zugangsstatus: Freier Zugang