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Medientyp:
E-Artikel
Titel:
Therapeutic bullfrog oil-based nanoemulsion for oral application: Development, characterization and stability
Beteiligte:
Rutckeviski, Renata;
Xavier, Francisco Humberto;
Morais, Andreza Rochelle Do Vale;
Amaral-Machado, Lucas;
Alencar, Everton Do Nascimento;
Genre, Julieta;
De Souza Araujo, Adriano Antunes;
Egito, Eryvaldo Socrates Tabosa Do
Erschienen:
Walter de Gruyter GmbH, 2019
Erschienen in:
Acta Pharmaceutica, 69 (2019) 1, Seite 33-48
Sprache:
Englisch
DOI:
10.2478/acph-2019-0001
ISSN:
1846-9558
Entstehung:
Anmerkungen:
Beschreibung:
Abstract The aim of this study was to develop, optimize, and characterize a stable therapeutic bullfrog oil based nanoemulsion for oral application using a rational experimental design approach. The optimized oral nanoemulsion contained 0.2 % sodium benzoate and 0.02 % propyl-paraben as preservatives; 0.1 % sucralose and 0.4 % acesulfam K as sweeteners and 0.1 % tutti-frutti as flavoring to mask the unpleasant organoleptic characteristics of bullfrog oil. The oral O/W-nanoemulsion showed the droplet size, PDI, zeta potential, and pH of 410 ± 8 nm, 0.20 ± 0.02, –38 ± 2.5 mV, and 6.43 ± 0.05, respectively. The optimized oral nanoemulsion showed a milky single-phase and optimal physical stability at 25 °C for 90 days. Indeed, higher oxidation induction time and lower formation of peroxides in the oral nanoemulsion were responsible for improving its stability. A therapeutic delivery system containing bullfrog oil for oral application was successfully developed and optimized with ideal thermo-oxidative stability.