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Schreiter, Nils Friedemann; Bartels, Ann-Mirja; Froeling, Vera; Steffen, Ingo; Pape, Ulrich-Frank; Beck, Alexander; Hamm, Bernd; Brenner, Winfried; Röttgen, Rainer

Searching for primaries in patients with neuroendocrine tumors (NET) of unknown primary and clinically suspected NET: Evaluation of Ga-68 DOTATOC PET/CT and In-111 DTPA octreotide SPECT/CT

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  • Medientyp: E-Artikel
  • Titel: Searching for primaries in patients with neuroendocrine tumors (NET) of unknown primary and clinically suspected NET: Evaluation of Ga-68 DOTATOC PET/CT and In-111 DTPA octreotide SPECT/CT
  • Beteiligte: Schreiter, Nils Friedemann; Bartels, Ann-Mirja; Froeling, Vera; Steffen, Ingo; Pape, Ulrich-Frank; Beck, Alexander; Hamm, Bernd; Brenner, Winfried; Röttgen, Rainer
  • Erschienen: Walter de Gruyter GmbH, 2014
  • Erschienen in: Radiology and Oncology
  • Sprache: Englisch
  • DOI: 10.2478/raon-2014-0018
  • ISSN: 1581-3207
  • Schlagwörter: Radiology, Nuclear Medicine and imaging ; Oncology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title> <jats:p> Background. To evaluate the clinical efficacy of In-111 DTPA octreotide SPECT/CT and Ga-68 DOTATOC PET/CT for detection of primary tumors in patients with either neuroendocrine tumor of unknown primary (NETUP) or clinically suspected primary NET (SNET). </jats:p> <jats:p>Patients and methods. A total of 123 patients were included from 2006 to 2009, 52 received Ga-68 DOTATOC PET/CT (NETUP, 33; SNET, 19) and 71 underwent In-111 DTPA octreotide SPECT/CT (50; 21). The standard of reference included histopathology or clinical verification based on follow-up examinations. </jats:p> <jats:p>Results. In the NETUP group Ga-68 DOTATOC detected primaries in 15 patients (45.5%) and In-111 DTPA octreotide in 4 patients (8%) (p &lt; 0.001); in the SNET group, only 2 primaries could be detected, all by Ga-68 DOTATOC. In patients with NETUP, primary tumors could be found significantly more often than in patients with SNET (p = 0.01). Out of these 21 patients 14 patients were operated. </jats:p> <jats:p>Conclusion. Ga-68 DOTATOC PET/CT is preferable to In-111 DTPA octreotide SPECT/CT when searching for primary NETs in patients with NETUP but should be used with caution in patients with SNET.</jats:p>
  • Zugangsstatus: Freier Zugang