Beschreibung:
<jats:p>Purpose. Comparative analysis of clinical efficacy and safety of inhalational general anesthesia (GA) with halothane and sevoflurane in premature infants with retinopathy of prematurity (ROP) during laser coagulation (LC) of the avascular retina. Material and methods. The clinical material included 284 children who underwent laser surgery of ROP in the period from 2008 to 2017 (method of continuous sampling). Introduction to anesthesia and maintenance of anesthesia was performed by inhalation of anesthetic (halothane or sevoflurane) with O2 using face mask and Mapleson breathing circuit. Two groups were formed: in the 1st group (167 people) halothane was used at anesthetic at oxygen concentration of 0.3 vol%, in the 2nd group (117 people) – sevoflurane at concentration of 1–1.5 vol%. Results. In case of GA with halothane in children of the 1st group, in 68 children (40.7%) developed negative reactions during anesthesia in the form of of respiratory depression, in several cases – up to pronounced bradypnea, bradycardia, prolonged awakening after surgery. In the 2nd group with GA with sevoflurane, negative reactions in the form of moderate bradycardia and bradypnea were observed only in 14 children (11.9%). All complications and reactions were promptly eliminated in all cases. Conclusion. Based on the obtained results, the optimal inhalation anesthetic for LC of retina in premature infants is sevoflurane in low concentrations (at the sedation level) using the Mapleson breathing circuit and face mask. With this method of anesthesia, the frequency of side effects of sevoflurane, negative reactions during anesthesia and the degree of their severity are extremely low. Key words: premature infants, retinopathy of premature, sevoflurane, general anesthesia, laser coagulation of the retina.</jats:p>