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Medientyp:
E-Artikel
Titel:
Bacterial Cholecystitis and Cholangiohepatitis in Common Marmosets (Callithrix Jacchus)
Beteiligte:
Powers, Sarah J;
Castell, Natalie;
Vistein, Rachel;
Kalloo, Anthony N;
Izzi, Jessica M;
Gabrielson, Kathleen L
Erschienen:
American Association for Laboratory Animal Science, 2023
Erschienen in:
Comparative Medicine, 73 (2023) 2, Seite 173-180
Sprache:
Englisch
DOI:
10.30802/aalas-cm-22-000075
ISSN:
1532-0820
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>The common marmoset (<jats:italic>Callithrix jacchus</jats:italic>), a New World NHP, has emerged as important animal model in multiple areas of translational biomedical research. The quality of translational research in marmosets depends on early diagnosis, treatment, and prevention of their spontaneous
diseases. Here, we characterize an outbreak of infectious cholangiohepatitis that affected 7 adult common marmosets in a single building over a 10-mo period. Marmosets presented for acute onset of lethargy, dull mentation, weight loss, dehydration, hyporexia, and hypothermia. Blood chemistries
at presentation revealed markedly elevated hepatic and biliary enzymes, but mild neutrophilia was detected in only 1 of the 7. Affected marmosets were unresponsive to rigorous treatment and died or were euthanized within 48 h of presentation. Gross and histopathologic examinations revealed
severe, necrosuppurative cholangiohepatitis and proliferative cholecystitis with bacterial colonies and an absence of gallstones. Perimortem and postmortem cultures revealed single or dual isolates of <jats:italic>Escherichia coli</jats:italic> and <jats:italic>Pseudomonas aeruginosa</jats:italic>. Other postmortem findings included
bile duct hyperplasia, periportal hepatitis, bile peritonitis, ulcerative gastroenteritis, and typhlitis. Environmental contamination of water supply equipment with <jats:italic>Pseudomonas</jats:italic> spp. was identified as the source of infection, but pathogenesis remains unclear. This type of severe, infectious
cholangiohepatitis with proliferative cholecystitis with <jats:italic>Pseudomonas</jats:italic> spp. had not been reported previously in marmosets, and we identified and here describe several contributing factors in addition to contaminated drinking water.</jats:p>