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Millesi, Matthias; Knosp, Engelbert; Mach, Georg; Hainfellner, Johannes A.; Ricken, Gerda; Trattnig, Siegfried; Gruber, Andreas

Focal irregularities in 7-Tesla MRI of unruptured intracranial aneurysms as an indicator for areas of altered blood-flow parameters

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  • Medientyp: E-Artikel
  • Titel: Focal irregularities in 7-Tesla MRI of unruptured intracranial aneurysms as an indicator for areas of altered blood-flow parameters
  • Beteiligte: Millesi, Matthias; Knosp, Engelbert; Mach, Georg; Hainfellner, Johannes A.; Ricken, Gerda; Trattnig, Siegfried; Gruber, Andreas
  • Erschienen: Journal of Neurosurgery Publishing Group (JNSPG), 2019
  • Erschienen in: Neurosurgical Focus
  • Sprache: Nicht zu entscheiden
  • DOI: 10.3171/2019.9.focus19489
  • ISSN: 1092-0684
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:sec><jats:title>OBJECTIVE</jats:title><jats:p>In the last several decades, various factors have been studied for a better evaluation of the risk of rupture in incidentally discovered intracranial aneurysms (IAs). With advanced MRI, attempts were made to delineate the wall of IAs to identify weak areas prone to rupture. However, the field strength of the MRI investigations was insufficient for reasonable image resolution in many of these studies. Therefore, the aim of this study was to analyze findings of IAs in ultra–high field MRI at 7 Tesla (7 T).</jats:p></jats:sec><jats:sec><jats:title>METHODS</jats:title><jats:p>Patients with incidentally found IAs of at least 5 mm in diameter were included in this study and underwent MRI investigations at 7 T. At this field strength a hyperintense intravascular signal can be observed on nonenhanced images with a brighter “rim effect” along the vessel wall. Properties of this rim effect were evaluated and compared with computational fluid dynamics (CFD) analyses.</jats:p></jats:sec><jats:sec><jats:title>RESULTS</jats:title><jats:p>Overall, 23 aneurysms showed sufficient image quality for further evaluation. In 22 aneurysms focal irregularities were identified within this rim effect. Areas of such irregularities showed significantly higher values in wall shear stress and vorticity compared to areas with a clearly visible rim effect (p = 0.043 in both).</jats:p></jats:sec><jats:sec><jats:title>CONCLUSIONS</jats:title><jats:p>A hyperintense rim effect along the vessel wall was observed in most cases. Focal irregularities within this rim effect showed higher values of the mean wall shear stress and vorticity when compared by CFD analyses. Therefore, these findings indicate alterations in blood flow in IAs within these areas.</jats:p></jats:sec>
  • Zugangsstatus: Freier Zugang