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Sandes-Freitas, Tainá Veras de; Cristelli, Marina Pontello; Requião-Moura, Lucio Roberto; Modelli de Andrade, Luís Gustavo; Viana, Laila Almeida; Garcia, Valter Duro; de Oliveira, Claudia Maria Costa; Esmeraldo, Ronaldo de Matos; de Lima, Paula Roberta; Charpiot, Ida Maria Maximina Fernandes; Ferreira, Teresa Cristina Alves; Franco, Rodrigo Fontanive; Costa, Kellen Micheline Alves Henrique; Simão, Denise Rodrigues; Ferreira, Gustavo Fernandes; Santana, Viviane Brandão Bandeira de Mello; Almeida, Ricardo Augusto Monteiro de Barros; Deboni, Luciane Monica; Saldanha, Anita Leme da Rocha; Noronha, Irene de Lourdes; Oliveira, Lívia Cláudio de; Carvalho, Deise De Boni Monteiro de; Oriá, Reinaldo Barreto; Medina-Pestana, Jose Osmar;

Temporal Reduction in COVID-19-Associated Fatality Among Kidney Transplant Recipients: The Brazilian COVID-19 Registry Cohort Study

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  • Medientyp: E-Artikel
  • Titel: Temporal Reduction in COVID-19-Associated Fatality Among Kidney Transplant Recipients: The Brazilian COVID-19 Registry Cohort Study
  • Beteiligte: Sandes-Freitas, Tainá Veras de; Cristelli, Marina Pontello; Requião-Moura, Lucio Roberto; Modelli de Andrade, Luís Gustavo; Viana, Laila Almeida; Garcia, Valter Duro; de Oliveira, Claudia Maria Costa; Esmeraldo, Ronaldo de Matos; de Lima, Paula Roberta; Charpiot, Ida Maria Maximina Fernandes; Ferreira, Teresa Cristina Alves; Franco, Rodrigo Fontanive; Costa, Kellen Micheline Alves Henrique; Simão, Denise Rodrigues; Ferreira, Gustavo Fernandes; Santana, Viviane Brandão Bandeira de Mello; Almeida, Ricardo Augusto Monteiro de Barros; Deboni, Luciane Monica; Saldanha, Anita Leme da Rocha; Noronha, Irene de Lourdes; Oliveira, Lívia Cláudio de; Carvalho, Deise De Boni Monteiro de; Oriá, Reinaldo Barreto; Medina-Pestana, Jose Osmar;
  • Erschienen: Frontiers Media SA, 2022
  • Erschienen in: Transplant International, 36 (2022)
  • Sprache: Nicht zu entscheiden
  • DOI: 10.3389/ti.2022.10205
  • ISSN: 1432-2277
  • Schlagwörter: Transplantation
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Data from the general population suggest that fatality rates declined during the course of the pandemic. This analysis, using data extracted from the Brazilian Kidney Transplant COVID-19 Registry, seeks to determine fatality rates over time since the index case on March 3rd, 2020. Data from hospitalized patients with RT-PCR positive SARS-CoV-2 infection from March to August 2020 (35 sites, 878 patients) were compared using trend tests according to quartiles (Q1: <72 days; Q2: 72–104 days; Q3: 105–140 days; Q4: >140 days after the index case). The 28-day fatality decreased from 29.5% (Q1) to 18.8% (Q4) (pfor-trend = 0.004). In multivariable analysis, patients diagnosed in Q4 showed a 35% reduced risk of death. The trend of reducing fatality was associated with a lower number of comorbidities (20.7–10.6%, pfor-trend = 0.002), younger age (55–53 years, pfor-trend = 0.062), and better baseline renal function (43.6–47.7 ml/min/1.73 m2, pfor-trend = 0.060), and were confirmed by multivariable analysis. The proportion of patients presenting dyspnea (pfor-trend = 0.001) and hypoxemia (pfor-trend < 0.001) at diagnosis, and requiring intensive care was also found reduced (pfor-trend = 0.038). Despite possible confounding variables and time-dependent sampling differences, we conclude that COVID-19-associated fatality decreased over time. Differences in demographics, clinical presentation, and treatment options might be involved.
  • Zugangsstatus: Freier Zugang