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Scorr, Laura M.; Cho, Hyun Joo; Kilic-Berkmen, Gamze; McKay, J. Lucas; Hallett, Mark; Klein, Christine; Baumer, Tobias; Berman, Brian D.; Feuerstein, Jeanne S.; Perlmutter, Joel S.; Berardelli, Alfredo; Ferrazzano, Gina; Wagle-Shukla, Aparna; Malaty, Irene A.; Jankovic, Joseph; Bellows, Steven T.; Barbano, Richard L.; Vidailhet, Marie; Roze, Emmanuel; Bonnet, Cecilia; Mahajan, Abhimanyu; LeDoux, Mark S.; Fung, Victor S.C.; Chang, Florence C.F.; [...]

Clinical Features and Evolution of Blepharospasm: A Multicenter International Cohort and Systematic Literature Review

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  • Medientyp: E-Artikel
  • Titel: Clinical Features and Evolution of Blepharospasm: A Multicenter International Cohort and Systematic Literature Review
  • Beteiligte: Scorr, Laura M.; Cho, Hyun Joo; Kilic-Berkmen, Gamze; McKay, J. Lucas; Hallett, Mark; Klein, Christine; Baumer, Tobias; Berman, Brian D.; Feuerstein, Jeanne S.; Perlmutter, Joel S.; Berardelli, Alfredo; Ferrazzano, Gina; Wagle-Shukla, Aparna; Malaty, Irene A.; Jankovic, Joseph; Bellows, Steven T.; Barbano, Richard L.; Vidailhet, Marie; Roze, Emmanuel; Bonnet, Cecilia; Mahajan, Abhimanyu; LeDoux, Mark S.; Fung, Victor S.C.; Chang, Florence C.F.; [...]
  • Erschienen: Frontiers Media SA, 2022
  • Erschienen in: Dystonia, 1 (2022)
  • Sprache: Nicht zu entscheiden
  • DOI: 10.3389/dyst.2022.10359
  • ISSN: 2813-2106
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Objective: Blepharospasm is a type of dystonia where the diagnosis is often delayed because its varied clinical manifestations are not well recognized. The purpose of this study was to provide a comprehensive picture of its clinical features including presenting features, motor features, and non-motor features.Methods: This was a two-part study. The first part involved a systematic literature review that summarized clinical features for 10,324 cases taken from 41 prior reports. The second part involved a summary of clinical features for 884 cases enrolled in a large multicenter cohort collected by the Dystonia Coalition investigators, along with an analysis of the factors that contribute to the spread of dystonia beyond the periocular region.Results: For cases in the literature and the Dystonia Coalition, blepharospasm emerged in the 50s and was more frequent in women. Many presented with non-specific motor symptoms such as increased blinking (51.9%) or non-motor sensory features such as eye soreness or pain (38.7%), photophobia (35.5%), or dry eyes (10.7%). Non-motor psychiatric features were also common including anxiety disorders (34–40%) and depression (21–24%). Among cases presenting with blepharospasm in the Dystonia Coalition cohort, 61% experienced spread of dystonia to other regions, most commonly the oromandibular region and neck. Features associated with spread included severity of blepharospasm, family history of dystonia, depression, and anxiety.Conclusions: This study provides a comprehensive summary of motor and non-motor features of blepharospasm, along with novel insights into factors that may be responsible for its poor diagnostic recognition and natural history.
  • Zugangsstatus: Freier Zugang