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van der Ree, Martijn H.; Cuculich, Phillip S.; van Herk, Marcel; Hugo, Geoffrey D.; Balt, Jippe C.; Bates, Matthew; Ho, Gordon; Pruvot, Etienne; Herrera-Siklody, Claudia; Hoeksema, Wiert F.; Lee, Justin; Lloyd, Michael S.; Kemme, Michiel J. B.; Sacher, Frederic; Tixier, Romain; Verhoeff, Joost J. C.; Balgobind, Brian V.; Robinson, Clifford G.; Rasch, Coen R. N.; Postema, Pieter G.

Interobserver variability in target definition for stereotactic arrhythmia radioablation

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  • Medientyp: E-Artikel
  • Titel: Interobserver variability in target definition for stereotactic arrhythmia radioablation
  • Beteiligte: van der Ree, Martijn H.; Cuculich, Phillip S.; van Herk, Marcel; Hugo, Geoffrey D.; Balt, Jippe C.; Bates, Matthew; Ho, Gordon; Pruvot, Etienne; Herrera-Siklody, Claudia; Hoeksema, Wiert F.; Lee, Justin; Lloyd, Michael S.; Kemme, Michiel J. B.; Sacher, Frederic; Tixier, Romain; Verhoeff, Joost J. C.; Balgobind, Brian V.; Robinson, Clifford G.; Rasch, Coen R. N.; Postema, Pieter G.
  • Erschienen: Frontiers Media SA, 2023
  • Erschienen in: Frontiers in Cardiovascular Medicine
  • Sprache: Nicht zu entscheiden
  • DOI: 10.3389/fcvm.2023.1267800
  • ISSN: 2297-055X
  • Schlagwörter: Cardiology and Cardiovascular Medicine
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:sec><jats:title>Background</jats:title><jats:p>Stereotactic arrhythmia radioablation (STAR) is a potential new therapy for patients with refractory ventricular tachycardia (VT). The arrhythmogenic substrate (target) is synthesized from clinical and electro-anatomical information. This study was designed to evaluate the baseline interobserver variability in target delineation for STAR.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Delineation software designed for research purposes was used. The study was split into three phases. Firstly, electrophysiologists delineated a well-defined structure in three patients (spinal canal). Secondly, observers delineated the VT-target in three patients based on case descriptions. To evaluate baseline performance, a basic workflow approach was used, no advanced techniques were allowed. Thirdly, observers delineated three predefined segments from the 17-segment model. Interobserver variability was evaluated by assessing volumes, variation in distance to the median volume expressed by the root-mean-square of the standard deviation (RMS-SD) over the target volume, and the Dice-coefficient.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Ten electrophysiologists completed the study. For the first phase interobserver variability was low as indicated by low variation in distance to the median volume (RMS-SD range: 0.02–0.02 cm) and high Dice-coefficients (mean: 0.97 ± 0.01). In the second phase distance to the median volume was large (RMS-SD range: 0.52–1.02 cm) and the Dice-coefficients low (mean: 0.40 ± 0.15). In the third phase, similar results were observed (RMS-SD range: 0.51–1.55 cm, Dice-coefficient mean: 0.31 ± 0.21).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Interobserver variability is high for manual delineation of the VT-target and ventricular segments. This evaluation of the baseline observer variation shows that there is a need for methods and tools to improve variability and allows for future comparison of interventions aiming to reduce observer variation, for STAR but possibly also for catheter ablation.</jats:p></jats:sec>
  • Zugangsstatus: Freier Zugang