> Detailanzeige

Melamed, Sharon; Politi, Boaz; Grauer, Ettie; Achdout, Hagit; Aftalion, Moshe; Gur, David; Tamir, Hadas; Yahalom-Ronen, Yfat; Maimon, Shlomy; Yitzhak, Efi; Weiss, Shay; Rosner, Amir; Erez, Noam; Yitzhaki, Shmuel; Shapira, Shmuel C; Paran, Nir; Mamroud, Emanuelle; Vagima, Yaron; Israely, Tomer

Monitoring Group Activity of Hamsters and Mice as a Novel Tool to Evaluate COVID-19 Progression, Convalescence, and rVSV-ΔG-Spike Vaccination Efficacy

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Monitoring Group Activity of Hamsters and Mice as a Novel Tool to Evaluate COVID-19 Progression, Convalescence, and rVSV-ΔG-Spike Vaccination Efficacy
  • Beteiligte: Melamed, Sharon; Politi, Boaz; Grauer, Ettie; Achdout, Hagit; Aftalion, Moshe; Gur, David; Tamir, Hadas; Yahalom-Ronen, Yfat; Maimon, Shlomy; Yitzhak, Efi; Weiss, Shay; Rosner, Amir; Erez, Noam; Yitzhaki, Shmuel; Shapira, Shmuel C; Paran, Nir; Mamroud, Emanuelle; Vagima, Yaron; Israely, Tomer
  • Erschienen: Frontiers Media SA, 2021
  • Erschienen in: Frontiers in Bioengineering and Biotechnology
  • Sprache: Nicht zu entscheiden
  • DOI: 10.3389/fbioe.2021.737627
  • ISSN: 2296-4185
  • Schlagwörter: Biomedical Engineering ; Histology ; Bioengineering ; Biotechnology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>The COVID-19 pandemic initiated a worldwide race toward the development of treatments and vaccines. Small animal models included the Syrian golden hamster and the K18-hACE2 mice infected with SARS-CoV-2 to display a disease state with some aspects of human COVID-19. A group activity of animals in their home cage continuously monitored by the HCMS100 (Home cage Monitoring System 100) was used as a sensitive marker of disease, successfully detecting morbidity symptoms of SARS-CoV-2 infection in hamsters and in K18-hACE2 mice. COVID-19 convalescent hamsters rechallenged with SARS-CoV-2 exhibited minor reduction in group activity compared to naive hamsters. To evaluate the rVSV-ΔG-spike vaccination efficacy against SARS-CoV-2, we used the HCMS100 to monitor the group activity of hamsters in their home cage. A single-dose rVSV-ΔG-spike vaccination of the immunized group showed a faster recovery than the nonimmunized infected hamsters, substantiating the efficacy of rVSV-ΔG-spike vaccine. HCMS100 offers nonintrusive, hands-free monitoring of a number of home cages of hamsters or mice modeling COVID-19.</jats:p>
  • Zugangsstatus: Freier Zugang