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Medientyp:
E-Artikel
Titel:
Metabolic Fuel for Epigenetic: Nuclear Production Meets Local Consumption
Beteiligte:
Boon, Ruben
Erschienen:
Frontiers Media SA, 2021
Erschienen in:
Frontiers in Genetics, 12 (2021)
Sprache:
Nicht zu entscheiden
DOI:
10.3389/fgene.2021.768996
ISSN:
1664-8021
Entstehung:
Anmerkungen:
Beschreibung:
Epigenetic modifications are responsible for finetuning gene expression profiles to the needs of cells, tissues, and organisms. To rapidly respond to environmental changes, the activity of chromatin modifiers critically depends on the concentration of a handful of metabolites that act as substrates and co-factors. In this way, these enzymes act as metabolic sensors that directly link gene expression to metabolic states. Although metabolites can easily diffuse through the nuclear pore, molecular mechanisms must be in place to regulate epigenetic marker deposition in specific nuclear subdomains or even on single loci. In this review, I explore the possible subcellular sites of metabolite production that influence the epigenome. From the relationship between cytoplasmic metabolism and nuclear metabolite deposition, I converse to the description of a compartmentalized nuclear metabolism. Last, I elaborate on the possibility of metabolic enzymes to operate in phase-separated nuclear microdomains formed by multienzyme and chromatin-bound protein complexes.