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Medientyp:
E-Artikel
Titel:
Contribution of Interleukin-17A to Retinal Degenerative Diseases
Beteiligte:
Zhong, Huimin;
Sun, Xiaodong
Erschienen:
Frontiers Media SA, 2022
Erschienen in:
Frontiers in Immunology, 13 (2022)
Sprache:
Nicht zu entscheiden
DOI:
10.3389/fimmu.2022.847937
ISSN:
1664-3224
Entstehung:
Anmerkungen:
Beschreibung:
Retinal degenerative diseases are a leading cause of vision loss and blindness throughout the world, characterized by chronic and progressive loss of neurons and/or myelin. One of the common features of retinal degenerative diseases and central neurodegenerative diseases is chronic neuroinflammation. Interleukin-17A (IL-17A) is the cytokine most closely related to disease in its family. Accumulating evidence suggests that IL-17A plays a key role in human retinal degenerative diseases, including age-related macular degeneration, diabetic retinopathy and glaucoma. This review aims to provide an overview of the role of IL-17A participating in the pathogenesis of retinal degenerative diseases, which may open new avenues for potential therapeutic interventions.