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Dollery, Stephen J.; Zurawski, Daniel V.; Bushnell, Ruth V.; Tobin, John K.; Wiggins, Taralyn J.; MacLeod, David A.; Tasker, Naomi J. P. E. R.; Alamneh, Yonas A.; Abu-Taleb, Rania; Czintos, Christine M.; Su, Wanwen; Escatte, Mariel G.; Meeks, Heather N.; Daly, Michael J.; Tobin, Gregory J.

Whole-cell vaccine candidates induce a protective response against virulent Acinetobacter baumannii

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  • Medientyp: E-Artikel
  • Titel: Whole-cell vaccine candidates induce a protective response against virulent Acinetobacter baumannii
  • Beteiligte: Dollery, Stephen J.; Zurawski, Daniel V.; Bushnell, Ruth V.; Tobin, John K.; Wiggins, Taralyn J.; MacLeod, David A.; Tasker, Naomi J. P. E. R.; Alamneh, Yonas A.; Abu-Taleb, Rania; Czintos, Christine M.; Su, Wanwen; Escatte, Mariel G.; Meeks, Heather N.; Daly, Michael J.; Tobin, Gregory J.
  • Erschienen: Frontiers Media SA, 2022
  • Erschienen in: Frontiers in Immunology
  • Sprache: Nicht zu entscheiden
  • DOI: 10.3389/fimmu.2022.941010
  • ISSN: 1664-3224
  • Schlagwörter: Immunology ; Immunology and Allergy
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p><jats:italic>Acinetobacter baumannii</jats:italic> causes multi-system diseases in both nosocomial settings and a pre-disposed general population. The bacterium is not only desiccation-resistant but also notoriously resistant to multiple antibiotics and drugs of last resort including carbapenem, colistin, and sulbactam. The World Health Organization has categorized carbapenem-resistant <jats:italic>A. baumannii</jats:italic> at the top of its critical pathogen list in a bid to direct urgent countermeasure development. Several early-stage vaccines have shown a range of efficacies in healthy mice, but no vaccine candidates have advanced into clinical trials. Herein, we report our findings that both an ionizing γ-radiation-inactivated and a non-ionizing ultraviolet C-inactivated whole-cell vaccine candidate protects neutropenic mice from pulmonary challenge with virulent AB5075, a particularly pathogenic isolate. In addition, we demonstrate that a humoral response is sufficient for this protection <jats:italic>via</jats:italic> the passive immunization of neutropenic mice.</jats:p>
  • Zugangsstatus: Freier Zugang