Treatment Induced Cytotoxic T-Cell Modulation in Multiple Myeloma Patients

Medientyp: E-Artikel

Titel: Treatment Induced Cytotoxic T-Cell Modulation in Multiple Myeloma Patients

Beteiligte: Barilà, Gregorio; Pavan, Laura; Vedovato, Susanna; Berno, Tamara; Lo Schirico, Mariella; Arangio Febbo, Massimiliano; Teramo, Antonella; Calabretto, Giulia; Vicenzetto, Cristina; Gasparini, Vanessa Rebecca; Fregnani, Anna; Manni, Sabrina; Trimarco, Valentina; Carraro, Samuela; Facco, Monica; Piazza, Francesco; Semenzato, Gianpietro; Zambello, Renato

Erschienen: Frontiers Media SA, 2021

Sprache: Nicht zu entscheiden

DOI: 10.3389/fonc.2021.682658

ISSN: 2234-943X

Schlagwörter: Cancer Research ; Oncology

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Beschreibung: The biology of plasma cell dyscrasias (PCD) involves both genetic and immune-related factors. Since genetic lesions are necessary but not sufficient for Multiple Myeloma (MM) evolution, several authors hypothesized that immune dysfunction involving both B and T cell counterparts plays a key role in the pathogenesis of the disease. The aim of this study is to evaluate the impact of cornerstone treatments for Multiple Myeloma into immune system shaping. A large series of 976 bone marrow samples from 735 patients affected by PCD was studied by flow analysis to identify discrete immune subsets. Treated MM samples displayed a reduction of CD4+ cells (p&lt;0.0001) and an increase of CD8+ (p&lt;0.0001), CD8+/DR+ (p&lt;0.0001) and CD3+/CD57+ (p&lt;0.0001) cells. Although these findings were to some extent demonstrated also following bortezomib treatment, a more pronounced cytotoxic polarization was shown after exposure to autologous stem cell transplantation (ASCT) and Lenalidomide (Len) treatment. As a matter of fact, samples of patients who received ASCT (n=110) and Len (n=118) were characterized, towards untreated patients (n=138 and n=130, respectively), by higher levels of CD8+ (p&lt;0.0001 and p&lt;0.0001, respectively), CD8+/DR+ (p=0.0252 and p=0.0001, respectively) and CD3+/CD57+ cells (p&lt;0.0001 and p=0.0006, respectively) and lower levels of CD4+ lymphocytes (p&lt;0.0001 and p=0.0005, respectively). We demonstrated that active MM patients are characterized by a relevant T cell modulation and that most of these changes are therapy-related. Current Myeloma treatments, notably ASCT and Len treatments, polarize immune system towards a dominant cytotoxic response, likely contributing to the anti-Myeloma effect of these regimens.

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