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Eschbach, Ralf S.; Hofmann, Markus; Späth, Lukas; Sheikh, Gabriel T.; Delker, Astrid; Lindner, Simon; Jurkschat, Klaus; Wängler, Carmen; Wängler, Björn; Schirrmacher, Ralf; Tiling, Reinhold; Brendel, Matthias; Wenter, Vera; Dekorsy, Franziska J.; Zacherl, Mathias J.; Todica, Andrei; Ilhan, Harun; Grawe, Freba; Cyran, Clemens C.; Unterrainer, Marcus; Rübenthaler, Johannes; Knösel, Thomas; Paul, Tanja; Boeck, Stefan; [...]

Comparison of somatostatin receptor expression in patients with neuroendocrine tumours with and without somatostatin analogue treatment imaged with [18F]SiTATE

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  • Medientyp: E-Artikel
  • Titel: Comparison of somatostatin receptor expression in patients with neuroendocrine tumours with and without somatostatin analogue treatment imaged with [18F]SiTATE
  • Beteiligte: Eschbach, Ralf S.; Hofmann, Markus; Späth, Lukas; Sheikh, Gabriel T.; Delker, Astrid; Lindner, Simon; Jurkschat, Klaus; Wängler, Carmen; Wängler, Björn; Schirrmacher, Ralf; Tiling, Reinhold; Brendel, Matthias; Wenter, Vera; Dekorsy, Franziska J.; Zacherl, Mathias J.; Todica, Andrei; Ilhan, Harun; Grawe, Freba; Cyran, Clemens C.; Unterrainer, Marcus; Rübenthaler, Johannes; Knösel, Thomas; Paul, Tanja; Boeck, Stefan; [...]
  • Erschienen: Frontiers Media SA, 2023
  • Erschienen in: Frontiers in Oncology, 13 (2023)
  • Sprache: Ohne Angabe
  • DOI: 10.3389/fonc.2023.992316
  • ISSN: 2234-943X
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: PurposeSomatostatin analogues (SSA) are frequently used in the treatment of neuroendocrine tumours. Recently, [18F]SiTATE entered the field of somatostatin receptor (SSR) positron emission tomography (PET)/computed tomography (CT) imaging. The purpose of this study was to compare the SSR-expression of differentiated gastroentero-pancreatic neuroendocrine tumours (GEP-NET) measured by [18F]SiTATE-PET/CT in patients with and without previous treatment with long-acting SSAs to evaluate if SSA treatment needs to be paused prior to [18F]SiTATE-PET/CT.Methods77 patients were examined with standardised [18F]SiTATE-PET/CT within clinical routine: 40 patients with long-acting SSAs up to 28 days prior to PET/CT examination and 37 patients without pre-treatment with SSAs. Maximum and mean standardized uptake values (SUVmax and SUVmean) of tumours and metastases (liver, lymphnode, mesenteric/peritoneal and bones) as well as representative background tissues (liver, spleen, adrenal gland, blood pool, small intestine, lung, bone) were measured, SUV ratios (SUVR) were calculated between tumours/metastases and liver, likewise between tumours/metastases and corresponding specific background, and compared between the two groups.ResultsSUVmean of liver (5.4 ± 1.5 vs. 6.8 ± 1.8) and spleen (17.5 ± 6.8 vs. 36.7 ± 10.3) were significantly lower (p < 0.001) and SUVmean of blood pool (1.7 ± 0.6 vs. 1.3 ± 0.3) was significantly higher (p < 0.001) in patients with SSA pre-treatment compared to patients without. No significant differences between tumour-to-liver and specific tumour-to-background SUVRs were observed between both groups (all p > 0.05).ConclusionIn patients previously treated with SSAs, a significantly lower SSR expression ([18F]SiTATE uptake) in normal liver and spleen tissue was observed, as previously reported for 68Ga-labelled SSAs, without significant reduction of tumour-to-background contrast. Therefore, there is no evidence that SSA treatment needs to be paused prior to [18F]SiTATE-PET/CT.
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