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Abumayyaleh, Mohammad; Nuñez-Gil, Iván J.; El-Battrawy, Ibrahim; Estrada, Vicente; Becerra-Muñoz, Víctor Manuel; Uribarri, Aitor; Fernández-Rozas, Inmaculada; Feltes, Gisela; Arroyo-Espliguero, Ramón; Trabattoni, Daniela; López Pais, Javier; Pepe, Martino; Romero, Rodolfo; Ortega-Armas, María Elizabeth; Bianco, Matteo; Astrua, Thamar Capel; D'Ascenzo, Fabrizio; Fabregat-Andres, Oscar; Ballester, Andrea; Marín, Francisco; Buonsenso, Danilo; Sanchez-Gimenez, Raul; Weiß, Christel; Fernandez Perez, Cristina; [...]

Sepsis of Patients Infected by SARS-CoV-2: Real-World Experience From the International HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score

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  • Medientyp: E-Artikel
  • Titel: Sepsis of Patients Infected by SARS-CoV-2: Real-World Experience From the International HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score
  • Beteiligte: Abumayyaleh, Mohammad; Nuñez-Gil, Iván J.; El-Battrawy, Ibrahim; Estrada, Vicente; Becerra-Muñoz, Víctor Manuel; Uribarri, Aitor; Fernández-Rozas, Inmaculada; Feltes, Gisela; Arroyo-Espliguero, Ramón; Trabattoni, Daniela; López Pais, Javier; Pepe, Martino; Romero, Rodolfo; Ortega-Armas, María Elizabeth; Bianco, Matteo; Astrua, Thamar Capel; D'Ascenzo, Fabrizio; Fabregat-Andres, Oscar; Ballester, Andrea; Marín, Francisco; Buonsenso, Danilo; Sanchez-Gimenez, Raul; Weiß, Christel; Fernandez Perez, Cristina; [...]
  • Erschienen: Frontiers Media SA, 2021
  • Erschienen in: Frontiers in Medicine
  • Sprache: Nicht zu entscheiden
  • DOI: 10.3389/fmed.2021.728102
  • ISSN: 2296-858X
  • Schlagwörter: General Medicine
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p><jats:bold>Background:</jats:bold> Patients with sepsis with a concomitant coronavirus (COVID-19) infection are related to a high morbidity and mortality rate. We investigated a large cohort of patients with sepsis with a concomitant COVID-19, and we developed a risk score for the estimation of sepsis risk in COVID-19.</jats:p><jats:p><jats:bold>Methods:</jats:bold> We conducted a sub-analysis from the international Health Outcome Predictive Evaluation Registry for COVID-19 (HOPE-COVID-19-Registry, NCT04334291). Out of 5,837 patients with COVID-19, 624 patients were diagnosed with sepsis according to the Sepsis-3 International Consensus.</jats:p><jats:p><jats:bold>Results:</jats:bold> In multivariable analysis, the following risk factors were identified as independent predictors for developing sepsis: current smoking, tachypnoea (&amp;gt;22 breath per minute), hemoptysis, peripheral oxygen saturation (SpO<jats:sub>2</jats:sub>) &amp;lt;92%, blood pressure (BP) (systolic BP &amp;lt;90 mmHg and diastolic BP &amp;lt;60 mmHg), Glasgow Coma Scale (GCS) &amp;lt;15, elevated procalcitonin (PCT), elevated troponin I (TnI), and elevated creatinine &amp;gt;1.5 mg/dl. By assigning odds ratio (OR) weighted points to these variables, the following three risk categories were defined to develop sepsis during admission: low-risk group (probability of sepsis 3.1–11.8%); intermediate-risk group (24.8–53.8%); and high-risk-group (58.3–100%). A score of 1 was assigned to current smoking, tachypnoea, decreased SpO<jats:sub>2</jats:sub>, decreased BP, decreased GCS, elevated PCT, TnI, and creatinine, whereas a score of 2 was assigned to hemoptysis.</jats:p><jats:p><jats:bold>Conclusions:</jats:bold> The HOPE Sepsis Score including nine parameters is useful in identifying high-risk COVID-19 patients to develop sepsis. Sepsis in COVID-19 is associated with a high mortality rate.</jats:p>
  • Zugangsstatus: Freier Zugang