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Popa, Delia Codruţa; Şerbănică, Andreea; Obrisca, Radu; Şerbănică, Ionut; Radu, Letiţia; Jercan, Cristina; Marcu, Andra; Bica, Ana; Asan, Minodora; Petran, Mădălina; Dragomir, Mihaela; Jardan, Cerasela; Ţică, Valeria; Gheorghe, Anca; Stoian, Irina; Coriu, Daniel; Coliţă, Anca; Coliţă, Andrei

Controversial Flow Cytometry Monitoring of a Relapse Case of Pediatric T Cell Acute Lymphoblastic Leukemia: A Case Report

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  • Medientyp: E-Artikel
  • Titel: Controversial Flow Cytometry Monitoring of a Relapse Case of Pediatric T Cell Acute Lymphoblastic Leukemia: A Case Report
  • Beteiligte: Popa, Delia Codruţa; Şerbănică, Andreea; Obrisca, Radu; Şerbănică, Ionut; Radu, Letiţia; Jercan, Cristina; Marcu, Andra; Bica, Ana; Asan, Minodora; Petran, Mădălina; Dragomir, Mihaela; Jardan, Cerasela; Ţică, Valeria; Gheorghe, Anca; Stoian, Irina; Coriu, Daniel; Coliţă, Anca; Coliţă, Andrei
  • Erschienen: Frontiers Media SA, 2022
  • Erschienen in: Frontiers in Medicine, 9 (2022)
  • Sprache: Nicht zu entscheiden
  • DOI: 10.3389/fmed.2022.858809
  • ISSN: 2296-858X
  • Schlagwörter: General Medicine
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Acute lymphoblastic leukemia (ALL) is the most frequent childhood cancer, with 80–85% represented by B cell ALL and only 15% by T cell ALL. T Cell ALL (T-ALL) carries a more reserved prognosis compared to B Cell ALL (B-ALL) with regard to response to treatment, risk of relapse, and overall survival. Progress made in current monitoring protocols such as via flow cytometry immunophenotyping (FCM) and by PCR-based amplification of antigen-receptor genes led to improved management of patients with ALL and superior rates of survival. Nevertheless, challenges remain in some clinical cases. This manuscript describes a unique case of T-ALL and raises awareness of such clinical challenges. The article presents an overview of the flow cytometry immunophenotyping at diagnosis and during treatment of a pediatric patient with T-ALL from Fundeni Clinical Institute. In this case, in spite of various therapeutic measures such as first-line chemotherapy for high risk group, salvage chemotherapy (FLAG), conditioning regimen (FLU-BU-TT-ATG), and stem cell transplant, a chemoresistance clone continued to be present.
  • Zugangsstatus: Freier Zugang