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Roberto, Natalia; Portella, Maria J.; Marquié, Marta; Alegret, Montserrat; Hernández, Isabel; Mauleón, Ana; Rosende-Roca, Maitee; Abdelnour, Carla; Esteban de Antonio, Ester; Tartari, Juan P.; Vargas, Liliana; López-Cuevas, Rogelio; Bojaryn, Urszula; Espinosa, Ana; Ortega, Gemma; Pérez-Cordón, Alba; Sanabria, Ángela; Orellana, Adelina; de Rojas, Itziar; Moreno-Grau, Sonia; Montrreal, Laura; Alarcón-Martín, Emilio; Ruíz, Agustín; Tárraga, Lluís; [...]

Neuropsychiatric Profile as a Predictor of Cognitive Decline in Mild Cognitive Impairment

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  • Medientyp: E-Artikel
  • Titel: Neuropsychiatric Profile as a Predictor of Cognitive Decline in Mild Cognitive Impairment
  • Beteiligte: Roberto, Natalia; Portella, Maria J.; Marquié, Marta; Alegret, Montserrat; Hernández, Isabel; Mauleón, Ana; Rosende-Roca, Maitee; Abdelnour, Carla; Esteban de Antonio, Ester; Tartari, Juan P.; Vargas, Liliana; López-Cuevas, Rogelio; Bojaryn, Urszula; Espinosa, Ana; Ortega, Gemma; Pérez-Cordón, Alba; Sanabria, Ángela; Orellana, Adelina; de Rojas, Itziar; Moreno-Grau, Sonia; Montrreal, Laura; Alarcón-Martín, Emilio; Ruíz, Agustín; Tárraga, Lluís; [...]
  • Erschienen: Frontiers Media SA, 2021
  • Erschienen in: Frontiers in Aging Neuroscience
  • Sprache: Nicht zu entscheiden
  • DOI: 10.3389/fnagi.2021.718949
  • ISSN: 1663-4365
  • Schlagwörter: Cognitive Neuroscience ; Aging
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p><jats:bold>Introduction:</jats:bold> Mild cognitive impairment is often associated with affective and other neuropsychiatric symptoms (NPS). This co-occurrence might have a relevant impact on disease progression, from MCI to dementia.</jats:p><jats:p><jats:bold>Objective:</jats:bold> The aim of this study was to explore the trajectories of cognitive decline in an MCI sample from a memory clinic, taking into consideration a perspective of isolated cognitive functions and based on NPS clusters, accounting for the different comorbid symptoms collected at their baseline visit.</jats:p><jats:p><jats:bold>Methods:</jats:bold> A total of 2,137 MCI patients were monitored over a 2.4-year period. Four clusters of NPS (i.e., Irritability, Apathy, Anxiety/Depression and Asymptomatic) were used to run linear mixed models to explore the interaction of cluster with time on cognitive trajectories using a comprehensive neuropsychological battery (NBACE) administered at baseline and at the three subsequent follow-ups.</jats:p><jats:p><jats:bold>Results:</jats:bold> A significant interaction between cluster and time in cognitive decline was found when verbal learning and cued-recall were explored (<jats:italic>p</jats:italic> = 0.002 for both memory functions). For verbal learning, the Irritability cluster had the largest effect size (0.69), whereas the Asymptomatic cluster showed the smallest effect size (0.22). For cued-recall, the Irritability cluster had the largest effect size among groups (0.64), and Anxiety/Depression had the smallest effect size (0.21).</jats:p><jats:p><jats:bold>Conclusions:</jats:bold> In MCI patients, the Irritability and Apathy NPS clusters shared similar patterns of worsening in memory functioning, which could point to these NPS as risk factors of a faster cognitive decline, acting as early prognostic markers and helping in the diagnostic process.</jats:p>
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