Kagerer, Sonja M.;
Schroeder, Clemens;
van Bergen, Jiri M. G.;
Schreiner, Simon J.;
Meyer, Rafael;
Steininger, Stefanie C.;
Vionnet, Laetitia;
Gietl, Anton F.;
Treyer, Valerie;
Buck, Alfred;
Pruessmann, Klaas P.;
Hock, Christoph;
Unschuld, Paul G.
Low Subicular Volume as an Indicator of Dementia-Risk Susceptibility in Old Age
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Medientyp:
E-Artikel
Titel:
Low Subicular Volume as an Indicator of Dementia-Risk Susceptibility in Old Age
Beteiligte:
Kagerer, Sonja M.;
Schroeder, Clemens;
van Bergen, Jiri M. G.;
Schreiner, Simon J.;
Meyer, Rafael;
Steininger, Stefanie C.;
Vionnet, Laetitia;
Gietl, Anton F.;
Treyer, Valerie;
Buck, Alfred;
Pruessmann, Klaas P.;
Hock, Christoph;
Unschuld, Paul G.
Erschienen:
Frontiers Media SA, 2022
Erschienen in:
Frontiers in Aging Neuroscience, 14 (2022)
Sprache:
Nicht zu entscheiden
DOI:
10.3389/fnagi.2022.811146
ISSN:
1663-4365
Entstehung:
Anmerkungen:
Beschreibung:
IntroductionHippocampal atrophy is an established Alzheimer’s Disease (AD) biomarker. Volume loss in specific subregions as measurable with ultra-high field magnetic resonance imaging (MRI) may reflect earliest pathological alterations.MethodsData from positron emission tomography (PET) for estimation of cortical amyloid β (Aβ) and high-resolution 7 Tesla T1 MRI for assessment of hippocampal subfield volumes were analyzed in 61 non-demented elderly individuals who were divided into risk-categories as defined by high levels of cortical Aβ and low performance in standardized episodic memory tasks.ResultsHigh cortical Aβ and low episodic memory interactively predicted subicular volume [F(3,57) = 5.90, p = 0.018]. The combination of high cortical Aβ and low episodic memory was associated with significantly lower subicular volumes, when compared to participants with high episodic memory (p = 0.004).DiscussionOur results suggest that low subicular volume is linked to established indicators of AD risk, such as increased cortical Aβ and low episodic memory. Our data support subicular volume as a marker of dementia-risk susceptibility in old-aged non-demented persons.