• Medientyp: E-Artikel
  • Titel: Low Subicular Volume as an Indicator of Dementia-Risk Susceptibility in Old Age
  • Beteiligte: Kagerer, Sonja M.; Schroeder, Clemens; van Bergen, Jiri M. G.; Schreiner, Simon J.; Meyer, Rafael; Steininger, Stefanie C.; Vionnet, Laetitia; Gietl, Anton F.; Treyer, Valerie; Buck, Alfred; Pruessmann, Klaas P.; Hock, Christoph; Unschuld, Paul G.
  • Erschienen: Frontiers Media SA, 2022
  • Erschienen in: Frontiers in Aging Neuroscience, 14 (2022)
  • Sprache: Nicht zu entscheiden
  • DOI: 10.3389/fnagi.2022.811146
  • ISSN: 1663-4365
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: IntroductionHippocampal atrophy is an established Alzheimer’s Disease (AD) biomarker. Volume loss in specific subregions as measurable with ultra-high field magnetic resonance imaging (MRI) may reflect earliest pathological alterations.MethodsData from positron emission tomography (PET) for estimation of cortical amyloid β (Aβ) and high-resolution 7 Tesla T1 MRI for assessment of hippocampal subfield volumes were analyzed in 61 non-demented elderly individuals who were divided into risk-categories as defined by high levels of cortical Aβ and low performance in standardized episodic memory tasks.ResultsHigh cortical Aβ and low episodic memory interactively predicted subicular volume [F(3,57) = 5.90, p = 0.018]. The combination of high cortical Aβ and low episodic memory was associated with significantly lower subicular volumes, when compared to participants with high episodic memory (p = 0.004).DiscussionOur results suggest that low subicular volume is linked to established indicators of AD risk, such as increased cortical Aβ and low episodic memory. Our data support subicular volume as a marker of dementia-risk susceptibility in old-aged non-demented persons.
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