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Medientyp:
E-Artikel
Titel:
The effect of antiplatelet and anticoagulant therapies on clinical outcome of patients undergoing decompressive craniectomy: a systematic review
Beteiligte:
Angelini, Chiara;
Zangrossi, Pietro;
Mantovani, Giorgio;
Cavallo, Michele Alessandro;
De Bonis, Pasquale;
Scerrati, Alba
Beschreibung:
<jats:sec><jats:title>Objective</jats:title><jats:p>This systematic review aims to investigate a potential correlation between the administration of antiplatelets (APs) or anticoagulants (ACs) and perioperative complications, with a particular focus on hemorrhagic events, in patients undergoing decompressive craniectomy (DC). Additionally, the secondary objective is to assess the neurological outcomes in patients undergoing DC while taking APs/ACs, comparing them to patients not on APs/ACs.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>The study utilized PubMed and Science Direct as primary online medical databases for the systematic review. Articles underwent screening based on title, abstract, and full-text review. Four studies meeting the inclusion criteria were selected for comprehensive analysis.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Our findings suggest that the administration of APs/ACs in patients undergoing DC does not significantly impact functional outcomes. Notably, the occurrence of rebleeding within 6 months and other complications, including infections, appears to be less frequent in patients taking APs compared to those not taking APs/ACs.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Literature-derived data on the association between APs/ACs and DC presented considerable heterogeneity and insufficient volume for robust statistical analysis. Consequently, a definitive conclusion regarding the influence of suspending or continuing these therapies on complications and clinical outcomes cannot be confidently reached at present. To address this, a large-scale prospective study is warranted to gather substantial and precise data, facilitating a nuanced understanding of how to balance the risks and benefits associated with antiplatelet and anticoagulant agents in the context of decompressive craniectomy.</jats:p></jats:sec>