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Thaler, Christian; Hartramph, Isabelle; Stellmann, Jan-Patrick; Heesen, Christoph; Bester, Maxim; Fiehler, Jens; Gellißen, Susanne

T1 Relaxation Times in the Cortex and Thalamus Are Associated With Working Memory and Information Processing Speed in Patients With Multiple Sclerosis

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  • Medientyp: E-Artikel
  • Titel: T1 Relaxation Times in the Cortex and Thalamus Are Associated With Working Memory and Information Processing Speed in Patients With Multiple Sclerosis
  • Beteiligte: Thaler, Christian; Hartramph, Isabelle; Stellmann, Jan-Patrick; Heesen, Christoph; Bester, Maxim; Fiehler, Jens; Gellißen, Susanne
  • Erschienen: Frontiers Media SA, 2021
  • Erschienen in: Frontiers in Neurology
  • Sprache: Nicht zu entscheiden
  • DOI: 10.3389/fneur.2021.789812
  • ISSN: 1664-2295
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p><jats:bold>Background:</jats:bold> Cortical and thalamic pathologies have been associated with cognitive impairment in patients with multiple sclerosis (MS).</jats:p><jats:p><jats:bold>Objective:</jats:bold> We aimed to quantify cortical and thalamic damage in patients with MS using a high-resolution T1 mapping technique and to evaluate the association of these changes with clinical and cognitive impairment.</jats:p><jats:p><jats:bold>Methods:</jats:bold> The study group consisted of 49 patients with mainly relapsing-remitting MS and 17 age-matched healthy controls who received 3T MRIs including a T1 mapping sequence (MP2RAGE). Mean T1 relaxation times (T1-RT) in the cortex and thalami were compared between patients with MS and healthy controls. Additionally, correlation analysis was performed to assess the relationship between MRI parameters and clinical and cognitive disability.</jats:p><jats:p><jats:bold>Results:</jats:bold> Patients with MS had significantly decreased normalized brain, gray matter, and white matter volumes, as well as increased T1-RT in the normal-appearing white matter, compared to healthy controls (<jats:italic>p</jats:italic> &amp;lt; 0.001). Partial correlation analysis with age, sex, and disease duration as covariates revealed correlations for T1-RT in the cortex (<jats:italic>r</jats:italic> = −0.33, <jats:italic>p</jats:italic> &amp;lt; 0.05), and thalami (right thalamus: <jats:italic>r</jats:italic> = −0.37, left thalamus: <jats:italic>r</jats:italic> = −0.50, both <jats:italic>p</jats:italic> &amp;lt; 0.05) with working memory and information processing speed, as measured by the Symbol-Digit Modalities Test.</jats:p><jats:p><jats:bold>Conclusion:</jats:bold> T1-RT in the cortex and thalamus correlate with information processing speed in patients with MS.</jats:p>
  • Zugangsstatus: Freier Zugang