Kangussu, Lucas M.;
Melo-Braga, Marcella Nunes;
de Souza Lima, Bruna Soares;
Santos, Robson A. S.;
de Andrade, Hélida Monteiro;
Campagnole-Santos, Maria José
Angiotensin-(1-7) Central Mechanisms After ICV Infusion in Hypertensive Transgenic (mRen2)27 Rats
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Medientyp:
E-Artikel
Titel:
Angiotensin-(1-7) Central Mechanisms After ICV Infusion in Hypertensive Transgenic (mRen2)27 Rats
Beteiligte:
Kangussu, Lucas M.;
Melo-Braga, Marcella Nunes;
de Souza Lima, Bruna Soares;
Santos, Robson A. S.;
de Andrade, Hélida Monteiro;
Campagnole-Santos, Maria José
Erschienen:
Frontiers Media SA, 2021
Erschienen in:
Frontiers in Neuroscience, 15 (2021)
Sprache:
Nicht zu entscheiden
DOI:
10.3389/fnins.2021.624249
ISSN:
1662-453X
Entstehung:
Anmerkungen:
Beschreibung:
Graphical AbstractHypothalamic mechanisms induced by ICV infusion of angiotensin-(1-7) in the transgenic (mRen2)27 hypertensive animals. Ang-(1-7) treatment modulated components of the renin-angiotensin system (RAS), attenuating increased levels of AT1 and ACE activity, and negatively modulated inflammatory profile, by increasing anti-inflammatory IL-10 and decreasing TNFα and iNOS in the hypothalamus. Further, altered oxidative stress/inflammation by ROS mediator, decreasing Uchl1 (ubiquitin carboxyl-terminal hydrolase isozyme L1) while increasing antioxidant peroxiredoxin 1 (figure was created with pictures from biorender.com).