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Guenver, Celia; Oualha, Mehdi; Levy, Corinne; Antona, Denise; Madhi, Fouad; Toubiana, Julie; Lachaume, Noémie; Javouhey, Etienne; Lorrot, Mathie; Yang, David Dawei; Levy, Michael; Caseris, Marion; Galeotti, Caroline; Ovaert, Caroline; Wiedemann, Arnaud; Girardin, Marie-Laure; Rybak, Alexis; Cohen, Robert; Belot, Alexandre

Educational Setting and SARS-CoV-2 Transmission Among Children With Multisystem Inflammatory Syndrome: A French National Surveillance System

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  • Medientyp: E-Artikel
  • Titel: Educational Setting and SARS-CoV-2 Transmission Among Children With Multisystem Inflammatory Syndrome: A French National Surveillance System
  • Beteiligte: Guenver, Celia; Oualha, Mehdi; Levy, Corinne; Antona, Denise; Madhi, Fouad; Toubiana, Julie; Lachaume, Noémie; Javouhey, Etienne; Lorrot, Mathie; Yang, David Dawei; Levy, Michael; Caseris, Marion; Galeotti, Caroline; Ovaert, Caroline; Wiedemann, Arnaud; Girardin, Marie-Laure; Rybak, Alexis; Cohen, Robert; Belot, Alexandre
  • Erschienen: Frontiers Media SA, 2021
  • Erschienen in: Frontiers in Pediatrics
  • Sprache: Nicht zu entscheiden
  • DOI: 10.3389/fped.2021.745364
  • ISSN: 2296-2360
  • Schlagwörter: Pediatrics, Perinatology and Child Health
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p><jats:bold>Background:</jats:bold>Multisystem inflammatory syndrome in children (MIS-C) is the most severe form associated with SARS-CoV-2 infection in children. To reduce the spread of SARS-CoV-2 at the population level, educational setting closure have been implemented in many countries. However, the direct benefit of school closure on the MIS-C burden remains to be explored. We aimed to assess the role of educational settings in SARS-CoV-2 transmission among children with MIS-C.</jats:p><jats:p><jats:bold>Methods:</jats:bold>We conducted a French national prospective surveillance of MIS-C, coordinated by Public Health France, from April 2020 to March 2021. During this period, we included all children with MIS-C fulfilling the WHO definition who were reported to Public Health France. For each child, we traced the source of SARS-CoV-2 transmission. The main outcome was the proportion of children with MIS-C, with educational setting-related SARS-CoV-2 infection, during the period of school opening.</jats:p><jats:p><jats:bold>Results:</jats:bold>We included 142 children fulfilling WHO criteria for MIS-C: 104 (70%) cases occurred during school opening periods. In total, 62/104 children (60%, 95%CI [50; 69]) had been contaminated by a household contact and 5/104 in educational settings (5%, 95%CI [2; 11]). Among children with MIS-C occurring during school closure periods, the proportion of household transmission remained similar (66%, 25/38).</jats:p><jats:p><jats:bold>Conclusion:</jats:bold>Children with MIS-C were mainly infected by SARS-CoV-2 within their family environment, and the educational setting played a marginal role in this transmission. This suggests that mitigating school attendance may not reduce substantially the burden of MIS-C.</jats:p>
  • Zugangsstatus: Freier Zugang