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Seidel, Alina; Jacobsen, Eva-Maria; Fabricius, Dorit; Class, Magdalena; Zernickel, Maria; Blum, Carmen; Conzelmann, Carina; Weil, Tatjana; Groß, Rüdiger; Bode, Sebastian F. N.; Renk, Hanna; Elling, Roland; Stich, Maximillian; Kirchhoff, Frank; Debatin, Klaus-Michael; Münch, Jan; Janda, Aleš

Serum neutralizing capacity and T-cell response against the omicron BA.1 variant in seropositive children and their parents one year after SARS-CoV-2 infection

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  • Medientyp: E-Artikel
  • Titel: Serum neutralizing capacity and T-cell response against the omicron BA.1 variant in seropositive children and their parents one year after SARS-CoV-2 infection
  • Beteiligte: Seidel, Alina; Jacobsen, Eva-Maria; Fabricius, Dorit; Class, Magdalena; Zernickel, Maria; Blum, Carmen; Conzelmann, Carina; Weil, Tatjana; Groß, Rüdiger; Bode, Sebastian F. N.; Renk, Hanna; Elling, Roland; Stich, Maximillian; Kirchhoff, Frank; Debatin, Klaus-Michael; Münch, Jan; Janda, Aleš
  • Erschienen: Frontiers Media SA, 2023
  • Erschienen in: Frontiers in Pediatrics
  • Sprache: Nicht zu entscheiden
  • DOI: 10.3389/fped.2023.1020865
  • ISSN: 2296-2360
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:sec><jats:title>Introduction</jats:title><jats:p>Durability of immune protection against reinfection with SARS-CoV-2 remains enigmatic, especially in the pediatric population and in the context of immune-evading variants of concern. Obviously, this knowledge is required for measures to contain the spread of infection and in selecting rational preventive measures.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Here, we investigated the serum neutralization capacity of 36 seropositive adults and 34 children approximately one year after infection with the ancestral Wuhan strain of SARS-CoV-2 by using a pseudovirus neutralization assay.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>We found that 88.9% of seropositive adult (32/36) and 94.1% of seropositive children (32/34) convalescents retained the neutralizing activity against the SARS-CoV-2 Wuhan strain (WT). Although, the neutralization effect against Omicron BA.1 (B.1.1.529.1) was significantly lower, 70.6% (24/34) of children and 41.7% (15/36) of adults possessed BA.1 cross-neutralizing antibodies. The spike 1 (S1)-specific T cell recall capacity using an activation-induced marker assay was analyzed in 18 adults and 16 children. All participants had detectable S1-specific CD4 T cells against WT, and 72.2% (13/18) adults and 81,3% (13/16) children had detectable S1 WT-specific CD8 T cells. CD4 cross-reactivity against BA.1 was demonstrated in all investigated adults (18/18), and 66.7% (12/18) adult participants had also detectable specific CD8 BA.1 T cells while we detected BA.1 S1 reactive CD4 and CD8 T cells in 81.3% (13/16) children.</jats:p></jats:sec><jats:sec><jats:title>Discussion</jats:title><jats:p>Together, our findings demonstrate that infection with the ancestral strain of SARS-CoV-2 in children as well as in adults induces robust serological as well as T cell memory responses that persist over at least 12 months. This suggests persistent immunological memory and partial cross-reactivity against Omicron BA.1.</jats:p></jats:sec>
  • Zugangsstatus: Freier Zugang