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Griffante, Gloria; Chandel, Shikha; Ferrante, Daniela; Caneparo, Valeria; Capello, Daniela; Bettio, Valentina; Borgogna, Cinzia; Aleni, Chiara; Esposito, Salvatore; Sarro, Andrea; Vasile, Alessandra; Comba, Marco; Testa, Tommaso; Cotrupi, Gianmarco; De Andrea, Marco; Bortoluzzi, Sara; Gariglio, Marisa

Persistence of Neutralizing Antibodies to SARS-CoV-2 in First Wave Infected Individuals at Ten Months Post-Infection: The UnIRSA Cohort Study

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  • Medientyp: E-Artikel
  • Titel: Persistence of Neutralizing Antibodies to SARS-CoV-2 in First Wave Infected Individuals at Ten Months Post-Infection: The UnIRSA Cohort Study
  • Beteiligte: Griffante, Gloria; Chandel, Shikha; Ferrante, Daniela; Caneparo, Valeria; Capello, Daniela; Bettio, Valentina; Borgogna, Cinzia; Aleni, Chiara; Esposito, Salvatore; Sarro, Andrea; Vasile, Alessandra; Comba, Marco; Testa, Tommaso; Cotrupi, Gianmarco; De Andrea, Marco; Bortoluzzi, Sara; Gariglio, Marisa
  • Erschienen: MDPI AG, 2021
  • Erschienen in: Viruses, 13 (2021) 11, Seite 2270
  • Sprache: Englisch
  • DOI: 10.3390/v13112270
  • ISSN: 1999-4915
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Longitudinal mapping of antibody-based SARS-CoV-2 immunity is critical for public health control of the pandemic and vaccine development. We performed a longitudinal analysis of the antibody-based immune response in a cohort of 100 COVID-19 individuals who were infected during the first wave of infection in northern Italy. The SARS-CoV-2 humoral response was tested using the COVID-SeroIndex, Kantaro Quantitative SARS-CoV-2 IgG Antibody RUO Kit (R&D Systems, Bio-Techne, Minneapolis, USA) and pseudotype-based neutralizing antibody assay. Using sequential serum samples collected from 100 COVID-19 recovered individuals from northern Italy—mostly with mild disease—at 2 and 10 months after their first positive PCR test, we show that 93% of them seroconverted at 2 months, with a geometric mean (GeoMean) half-maximal neutralization titer (NT50) of 387.9. Among the 35 unvaccinated subjects retested at 10 months, 7 resulted seronegative, with an 80% drop in seropositivity, while 28 showed decreased anti-receptor binding domain (RBD) and anti-spike (S) IgG titers, with a GeoMean NT50 neutralization titer dropping to 163.5. As an NT50 > 100 is known to confer protection from SARS-CoV-2 re-infection, our data show that the neutralizing activity elicited by the natural infection has lasted for at least 10 months in a large fraction of subjects.
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