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Kamau, Joseph; Ergunay, Koray; Webala, Paul W.; Justi, Silvia A.; Bourke, Brian P.; Kamau, Maureen W.; Hassell, James; Chege, Mary N.; Mwaura, David K.; Simiyu, Cynthia; Kibiwot, Sospeter; Onyuok, Samson; Caicedo-Quiroga, Laura; Li, Tao; Zimmerman, Dawn M.; Linton, Yvonne-Marie

A Novel Coronavirus and a Broad Range of Viruses in Kenyan Cave Bats

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  • Medientyp: E-Artikel
  • Titel: A Novel Coronavirus and a Broad Range of Viruses in Kenyan Cave Bats
  • Beteiligte: Kamau, Joseph; Ergunay, Koray; Webala, Paul W.; Justi, Silvia A.; Bourke, Brian P.; Kamau, Maureen W.; Hassell, James; Chege, Mary N.; Mwaura, David K.; Simiyu, Cynthia; Kibiwot, Sospeter; Onyuok, Samson; Caicedo-Quiroga, Laura; Li, Tao; Zimmerman, Dawn M.; Linton, Yvonne-Marie
  • Erschienen: MDPI AG, 2022
  • Erschienen in: Viruses, 14 (2022) 12, Seite 2820
  • Sprache: Englisch
  • DOI: 10.3390/v14122820
  • ISSN: 1999-4915
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Background and Methods: To investigate virus diversity in hot zones of probable pathogen spillover, 54 oral-fecal swabs were processed from five bat species collected from three cave systems in Kenya, using metagenome sequencing. Results: Viruses belonging to the Astroviridae, Circoviridae, Coronaviridae, Dicistroviridae, Herpesviridae and Retroviridae were detected, with unclassified viruses. Retroviral sequences were prevalent; 74.1% of all samples were positive, with distinct correlations between virus, site and host bat species. Detected retroviruses comprised Myotis myotis, Myotis ricketti, Myotis daubentonii and Galidia endogenous retroviruses, murine leukemia virus-related virus and Rhinolophus ferrumequinum retrovirus (RFRV). A near-complete genome of a local RFRV strain with identical genome organization and 2.8% nucleotide divergence from the prototype isolate was characterized. Bat coronavirus sequences were detected with a prevalence of 24.1%, where analyses on the ORF1ab region revealed a novel alphacoronavirus lineage. Astrovirus sequences were detected in 25.9%of all samples, with considerable diversity. In 9.2% of the samples, other viruses including Actinidia yellowing virus 2, bat betaherpesvirus, Bole tick virus 4, Cyclovirus and Rhopalosiphum padi virus were identified. Conclusions: Further monitoring of bats across Kenya is essential to facilitate early recognition of possibly emergent zoonotic viruses.
  • Zugangsstatus: Freier Zugang