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Breslin, Thomas; Paino, Jason; Wegner, Marie; Engels, Elette; Fiedler, Stefan; Forrester, Helen; Rennau, Hannes; Bustillo, John; Cameron, Matthew; Häusermann, Daniel; Hall, Christopher; Krause, Dieter; Hildebrandt, Guido; Lerch, Michael; Schültke, Elisabeth

A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy: Design, Dosimetry and Biological Pilot Study

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  • Medientyp: E-Artikel
  • Titel: A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy: Design, Dosimetry and Biological Pilot Study
  • Beteiligte: Breslin, Thomas; Paino, Jason; Wegner, Marie; Engels, Elette; Fiedler, Stefan; Forrester, Helen; Rennau, Hannes; Bustillo, John; Cameron, Matthew; Häusermann, Daniel; Hall, Christopher; Krause, Dieter; Hildebrandt, Guido; Lerch, Michael; Schültke, Elisabeth
  • Erschienen: MDPI AG, 2023
  • Erschienen in: Biomimetics, 8 (2023) 2, Seite 230
  • Sprache: Englisch
  • DOI: 10.3390/biomimetics8020230
  • ISSN: 2313-7673
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>The production of anthropomorphic phantoms generated from tissue-equivalent materials is challenging but offers an excellent copy of the typical environment encountered in typical patients. High-quality dosimetry measurements and the correlation of the measured dose with the biological effects elicited by it are a prerequisite in preparation of clinical trials with novel radiotherapy approaches. We designed and produced a partial upper arm phantom from tissue-equivalent materials for use in experimental high-dose-rate radiotherapy. The phantom was compared to original patient data using density values and Hounsfield units obtained from CT scans. Dose simulations were conducted for broad-beam irradiation and microbeam radiotherapy (MRT) and compared to values measured in a synchrotron radiation experiment. Finally, we validated the phantom in a pilot experiment with human primary melanoma cells.</jats:p>
  • Zugangsstatus: Freier Zugang