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Permuth, Jennifer; Dezsi, Kaleena; Vyas, Shraddha; Ali, Karla; Basinski, Toni; Utuama, Ovie; Denbo, Jason; Klapman, Jason; Dam, Aamir; Carballido, Estrella; Kim, Dae; Pimiento, Jose; Powers, Benjamin; Otto, Amy; Choi, Jung; Chen, Dung-Tsa; Teer, Jamie; Beato, Francisca; Ward, Alina; Cortizas, Elena; Whisner, Suzanne; Williams, Iverson; Riner, Andrea; Tardif, Kenneth; [...]

The Florida Pancreas Collaborative Next-Generation Biobank: Infrastructure to Reduce Disparities and Improve Survival for a Diverse Cohort of Patients with Pancreatic Cancer

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  • Medientyp: E-Artikel
  • Titel: The Florida Pancreas Collaborative Next-Generation Biobank: Infrastructure to Reduce Disparities and Improve Survival for a Diverse Cohort of Patients with Pancreatic Cancer
  • Beteiligte: Permuth, Jennifer; Dezsi, Kaleena; Vyas, Shraddha; Ali, Karla; Basinski, Toni; Utuama, Ovie; Denbo, Jason; Klapman, Jason; Dam, Aamir; Carballido, Estrella; Kim, Dae; Pimiento, Jose; Powers, Benjamin; Otto, Amy; Choi, Jung; Chen, Dung-Tsa; Teer, Jamie; Beato, Francisca; Ward, Alina; Cortizas, Elena; Whisner, Suzanne; Williams, Iverson; Riner, Andrea; Tardif, Kenneth; [...]
  • Erschienen: MDPI AG, 2021
  • Erschienen in: Cancers
  • Sprache: Englisch
  • DOI: 10.3390/cancers13040809
  • ISSN: 2072-6694
  • Schlagwörter: Cancer Research ; Oncology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>Background: Well-annotated, high-quality biorepositories provide a valuable platform to support translational research. However, most biorepositories have poor representation of minority groups, limiting the ability to address health disparities. Methods: We describe the establishment of the Florida Pancreas Collaborative (FPC), the first state-wide prospective cohort study and biorepository designed to address the higher burden of pancreatic cancer (PaCa) in African Americans (AA) compared to Non-Hispanic Whites (NHW) and Hispanic/Latinx (H/L). We provide an overview of stakeholders; study eligibility and design; recruitment strategies; standard operating procedures to collect, process, store, and transfer biospecimens, medical images, and data; our cloud-based data management platform; and progress regarding recruitment and biobanking. Results: The FPC consists of multidisciplinary teams from fifteen Florida medical institutions. From March 2019 through August 2020, 350 patients were assessed for eligibility, 323 met inclusion/exclusion criteria, and 305 (94%) enrolled, including 228 NHW, 30 AA, and 47 H/L, with 94%, 100%, and 94% participation rates, respectively. A high percentage of participants have donated blood (87%), pancreatic tumor tissue (41%), computed tomography scans (76%), and questionnaires (62%). Conclusions: This biorepository addresses a critical gap in PaCa research and has potential to advance translational studies intended to minimize disparities and reduce PaCa-related morbidity and mortality.</jats:p>
  • Zugangsstatus: Freier Zugang