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Medientyp:
E-Artikel
Titel:
Circulating and Tumor-Associated Neutrophils in the Era of Immune Checkpoint Inhibitors: Dynamics, Phenotypes, Metabolism, and Functions
Beteiligte:
Gibellini, Lara;
Borella, Rebecca;
Santacroce, Elena;
Serattini, Eugenia;
Boraldi, Federica;
Quaglino, Daniela;
Aramini, Beatrice;
De Biasi, Sara;
Cossarizza, Andrea
Erschienen:
MDPI AG, 2023
Erschienen in:
Cancers, 15 (2023) 13, Seite 3327
Sprache:
Englisch
DOI:
10.3390/cancers15133327
ISSN:
2072-6694
Entstehung:
Anmerkungen:
Beschreibung:
Neutrophils are the most abundant myeloid cells in the blood and are a considerable immunological component of the tumor microenvironment. However, their functional importance has often been ignored, as they have always been considered a mono-dimensional population of terminally differentiated, short-living cells. During the last decade, the use of cutting-edge, single-cell technologies has revolutionized the classical view of these cells, unmasking their phenotypic and functional heterogeneity. In this review, we summarize the emerging concepts in the field of neutrophils in cancer, by reviewing the recent literature on the heterogeneity of both circulating neutrophils and tumor-associated neutrophils, as well as their possible significance in tumor prognosis and resistance to immune checkpoint inhibitors.