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Serradilla-Martín, Mario; Villodre, Celia; Falgueras-Verdaguer, Laia; Zambudio-Carroll, Natalia; Castell-Gómez, José T.; Blas-Laina, Juan L.; Borrego-Estella, Vicente; Domingo-del-Pozo, Carlos; García-Plaza, Gabriel; González-Rodríguez, Francisco J.; Montalvá-Orón, Eva M.; Moya-Herraiz, Ángel; Paterna-López, Sandra; Suárez-Muñoz, Miguel A.; Alkorta-Zuloaga, Maialen; Blanco-Fernández, Gerardo; Dabán-Collado, Enrique; Gómez-Bravo, Miguel A.; Miota-de-Llamas, José I.; Rotellar, Fernando; Sánchez-Pérez, Belinda; Sánchez-Cabús, Santiago; Pacheco-Sánchez, David; Rodríguez-Sanjuan, Juan C.; [...]

Feasibility and Short-Term Outcomes in Liver-First Approach: A Spanish Snapshot Study (the RENACI Project)

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  • Medientyp: E-Artikel
  • Titel: Feasibility and Short-Term Outcomes in Liver-First Approach: A Spanish Snapshot Study (the RENACI Project)
  • Beteiligte: Serradilla-Martín, Mario; Villodre, Celia; Falgueras-Verdaguer, Laia; Zambudio-Carroll, Natalia; Castell-Gómez, José T.; Blas-Laina, Juan L.; Borrego-Estella, Vicente; Domingo-del-Pozo, Carlos; García-Plaza, Gabriel; González-Rodríguez, Francisco J.; Montalvá-Orón, Eva M.; Moya-Herraiz, Ángel; Paterna-López, Sandra; Suárez-Muñoz, Miguel A.; Alkorta-Zuloaga, Maialen; Blanco-Fernández, Gerardo; Dabán-Collado, Enrique; Gómez-Bravo, Miguel A.; Miota-de-Llamas, José I.; Rotellar, Fernando; Sánchez-Pérez, Belinda; Sánchez-Cabús, Santiago; Pacheco-Sánchez, David; Rodríguez-Sanjuan, Juan C.; [...]
  • Erschienen: MDPI AG, 2024
  • Erschienen in: Cancers
  • Sprache: Englisch
  • DOI: 10.3390/cancers16091676
  • ISSN: 2072-6694
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>(1) Background: The liver-first approach may be indicated for colorectal cancer patients with synchronous liver metastases to whom preoperative chemotherapy opens a potential window in which liver resection may be undertaken. This study aims to present the data of feasibility and short-term outcomes in the liver-first approach. (2) Methods: A prospective observational study was performed in Spanish hospitals that had a medium/high-volume of HPB surgeries from 1 June 2019 to 31 August 2020. (3) Results: In total, 40 hospitals participated, including a total of 2288 hepatectomies, 1350 for colorectal liver metastases, 150 of them (11.1%) using the liver-first approach, 63 (42.0%) in hospitals performing &lt;50 hepatectomies/year. The proportion of patients as ASA III was significantly higher in centers performing ≥50 hepatectomies/year (difference: 18.9%; p = 0.0213). In 81.1% of the cases, the primary tumor was in the rectum or sigmoid colon. In total, 40% of the patients underwent major hepatectomies. The surgical approach was open surgery in 87 (58.0%) patients. Resection margins were R0 in 78.5% of the patients. In total, 40 (26.7%) patients had complications after the liver resection and 36 (27.3%) had complications after the primary resection. One-hundred and thirty-two (89.3%) patients completed the therapeutic regime. (4) Conclusions: There were no differences in the surgical outcomes between the centers performing &lt;50 and ≥50 hepatectomies/year. Further analysis evaluating factors associated with clinical outcomes and determining the best candidates for this approach will be subsequently conducted.</jats:p>
  • Zugangsstatus: Freier Zugang