Molecular Insights into the Thrombotic and Microvascular Injury in Placental Endothelium of Women with Mild or Severe COVID-19

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Titel: Molecular Insights into the Thrombotic and Microvascular Injury in Placental Endothelium of Women with Mild or Severe COVID-19

Beteiligte: Flores-Pliego, Arturo; Miranda, Jael; Vega-Torreblanca, Sara; Valdespino-Vázquez, Yolotzin; Helguera-Repetto, Cecilia; Espejel-Nuñez, Aurora; Borboa-Olivares, Héctor; Espino y Sosa, Salvador; Mateu-Rogell, Paloma; León-Juárez, Moisés; Ramírez-Santes, Victor; Cardona-Pérez, Arturo; Villegas-Mota, Isabel; Torres-Torres, Johnatan; Juárez-Reyes, Ángeles; Rizo-Pica, Thelma; González, Rosa O.; González-Mariscal, Lorenza; Estrada-Gutierrez, Guadalupe

Erschienen: MDPI AG, 2021

Sprache: Englisch

DOI: 10.3390/cells10020364

ISSN: 2073-4409

Schlagwörter: General Medicine

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Beschreibung: Clinical manifestations of coronavirus disease 2019 (COVID-19) in pregnant women are diverse, and little is known of the impact of the disease on placental physiology. Severe acute respiratory syndrome coronavirus (SARS-CoV-2) has been detected in the human placenta, and its binding receptor ACE2 is present in a variety of placental cells, including endothelium. Here, we analyze the impact of COVID-19 in placental endothelium, studying by immunofluorescence the expression of von Willebrand factor (vWf), claudin-5, and vascular endothelial (VE) cadherin in the decidua and chorionic villi of placentas from women with mild and severe COVID-19 in comparison to healthy controls. Our results indicate that: (1) vWf expression increases in the endothelium of decidua and chorionic villi of placentas derived from women with COVID-19, being higher in severe cases; (2) Claudin-5 and VE-cadherin expression decrease in the decidua and chorionic villus of placentas from women with severe COVID-19 but not in those with mild disease. Placental histological analysis reveals thrombosis, infarcts, and vascular wall remodeling, confirming the deleterious effect of COVID-19 on placental vessels. Together, these results suggest that placentas from women with COVID-19 have a condition of leaky endothelium and thrombosis, which is sensitive to disease severity.

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