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Piccinno, Maria Serena; Petrachi, Tiziana; Pignatti, Marco; Murgia, Alba; Grisendi, Giulia; Candini, Olivia; Resca, Elisa; Bergamini, Valentina; Ganzerli, Francesco; Portone, Alberto; Mastrolia, Ilenia; Chiavelli, Chiara; Castelli, Ilaria; Bernabei, Daniela; Tagliazucchi, Mara; Bonetti, Elisa; Lolli, Francesca; De Santis, Giorgio; Dominici, Massimo; Veronesi, Elena

Human Adipose Mesenchymal Stromal/Stem Cells Improve Fat Transplantation Performance

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  • Medientyp: E-Artikel
  • Titel: Human Adipose Mesenchymal Stromal/Stem Cells Improve Fat Transplantation Performance
  • Beteiligte: Piccinno, Maria Serena; Petrachi, Tiziana; Pignatti, Marco; Murgia, Alba; Grisendi, Giulia; Candini, Olivia; Resca, Elisa; Bergamini, Valentina; Ganzerli, Francesco; Portone, Alberto; Mastrolia, Ilenia; Chiavelli, Chiara; Castelli, Ilaria; Bernabei, Daniela; Tagliazucchi, Mara; Bonetti, Elisa; Lolli, Francesca; De Santis, Giorgio; Dominici, Massimo; Veronesi, Elena
  • Erschienen: MDPI AG, 2022
  • Erschienen in: Cells
  • Sprache: Englisch
  • DOI: 10.3390/cells11182799
  • ISSN: 2073-4409
  • Schlagwörter: General Medicine
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>The resorption rate of autologous fat transfer (AFT) is 40–60% of the implanted tissue, requiring new surgical strategies for tissue reconstruction. We previously demonstrated in a rabbit model that AFT may be empowered by adipose-derived mesenchymal stromal/stem cells (AD-MSCs), which improve graft persistence by exerting proangiogenic/anti-inflammatory effects. However, their fate after implantation requires more investigation. We report a xenograft model of adipose tissue engineering in which NOD/SCID mice underwent AFT with/without human autologous AD-MSCs and were monitored for 180 days (d). The effect of AD-MSCs on AFT grafting was also monitored by evaluating the expression of CD31 and F4/80 markers. Green fluorescent protein-positive AD-MSCs (AD-MSC-GFP) were detected in fibroblastoid cells 7 days after transplantation and in mature adipocytes at 60 days, indicating both persistence and differentiation of the implanted cells. This evidence also correlated with the persistence of a higher graft weight in AFT-AD-MSC compared to AFT alone treated mice. An observation up to 180 d revealed a lower resorption rate and reduced lipidic cyst formation in the AFT-AD-MSC group, suggesting a long-term action of AD-MSCs in support of AFT performance and an anti-inflammatory/proangiogenic activity. Together, these data indicate the protective role of adipose progenitors in autologous AFT tissue resorption.</jats:p>
  • Zugangsstatus: Freier Zugang