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Minieri, Marilena; Di Lecce, Vito N.; Lia, Maria Stella; Maurici, Massimo; Leonardis, Francesca; Longo, Susanna; Colangeli, Luca; Paganelli, Carla; Levantesi, Stefania; Terrinoni, Alessandro; Malagnino, Vincenzo; Brunetti, Domenico J.; Giovannelli, Alfredo; Pieri, Massimo; Ciotti, Marco; D’Agostini, Cartesio; Gabriele, Mariachiara; Bernardini, Sergio; Legramante, Jacopo M.

Predictive Value of MR-proADM in the Risk Stratification and in the Adequate Care Setting of COVID-19 Patients Assessed at the Triage of the Emergency Department

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  • Medientyp: E-Artikel
  • Titel: Predictive Value of MR-proADM in the Risk Stratification and in the Adequate Care Setting of COVID-19 Patients Assessed at the Triage of the Emergency Department
  • Beteiligte: Minieri, Marilena; Di Lecce, Vito N.; Lia, Maria Stella; Maurici, Massimo; Leonardis, Francesca; Longo, Susanna; Colangeli, Luca; Paganelli, Carla; Levantesi, Stefania; Terrinoni, Alessandro; Malagnino, Vincenzo; Brunetti, Domenico J.; Giovannelli, Alfredo; Pieri, Massimo; Ciotti, Marco; D’Agostini, Cartesio; Gabriele, Mariachiara; Bernardini, Sergio; Legramante, Jacopo M.
  • Erschienen: MDPI AG, 2022
  • Erschienen in: Diagnostics
  • Sprache: Englisch
  • DOI: 10.3390/diagnostics12081971
  • ISSN: 2075-4418
  • Schlagwörter: Clinical Biochemistry
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>In the past two pandemic years, Emergency Departments (ED) have been overrun with COVID-19-suspicious patients. Some data on the role played by laboratory biomarkers in the early risk stratification of COVID-19 patients have been recently published. The aim of this study is to assess the potential role of the new biomarker mid-regional proadrenomedullin (MR-proADM) in stratifying the in-hospital mortality risk of COVID-19 patients at the triage. A further goal of the present study is to evaluate whether MR-proADM together with other biochemical markers could play a key role in assessing the correct care level of these patients. Data from 321 consecutive patients admitted to the triage of the ED with a COVID-19 infection were analyzed. Epidemiological; demographic; clinical; laboratory; and outcome data were assessed. All the biomarkers analyzed showed an important role in predicting mortality. In particular, an increase of MR-proADM level at ED admission was independently associated with a threefold higher risk of IMV. MR-proADM showed greater ROC curves and AUC when compared to other laboratory biomarkers for the primary endpoint such as in-hospital mortality, except for CRP. This study shows that MR-proADM seems to be particularly effective for early predicting mortality and the need of ventilation in COVID-19 patients admitted to the ED.</jats:p>
  • Zugangsstatus: Freier Zugang