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Medientyp:
E-Artikel
Titel:
Replication Fork Protection Factors Controlling R-Loop Bypass and Suppression
Beteiligte:
Chang, Emily;
Stirling, Peter
Erschienen:
MDPI AG, 2017
Erschienen in:
Genes, 8 (2017) 1, Seite 33
Sprache:
Englisch
DOI:
10.3390/genes8010033
ISSN:
2073-4425
Entstehung:
Anmerkungen:
Beschreibung:
Replication–transcription conflicts have been a well-studied source of genome instability for many years and have frequently been linked to defects in RNA processing. However, recent characterization of replication fork-associated proteins has revealed that defects in fork protection can directly or indirectly stabilize R-loop structures in the genome and promote transcription–replication conflicts that lead to genome instability. Defects in essential DNA replication-associated activities like topoisomerase, or the minichromosome maintenance (MCM) helicase complex, as well as fork-associated protection factors like the Fanconi anemia pathway, both appear to mitigate transcription–replication conflicts. Here, we will highlight recent advances that support the concept that normal and robust replisome function itself is a key component of mitigating R-loop coupled genome instability.