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Medientyp:
E-Artikel
Titel:
Changes in Proteome of Fibroblasts Isolated from Psoriatic Skin Lesions
Beteiligte:
Gęgotek, Agnieszka;
Domingues, Pedro;
Wroński, Adam;
Skrzydlewska, Elżbieta
Erschienen:
MDPI AG, 2020
Erschienen in:International Journal of Molecular Sciences
Sprache:
Englisch
DOI:
10.3390/ijms21155363
ISSN:
1422-0067
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>The dermal fibroblasts are in constant contact with the cells of the immune system and skin epidermis. Therefore, they are essential for the development of lesions in psoriasis. The aim of this study was to assess the changes in the proteomic profile of fibroblasts in the dermis of psoriasis patients, and to discuss the most significant changes and their potential consequences. The proteomic results indicate that fibroblast dysfunction arises from the upregulation of proinflammatory factors and antioxidant proteins, as well as those involved in signal transduction and participating in proteolytic processes. Moreover, downregulated proteins in psoriatic fibroblasts are mainly responsible for the transcription/translation processes, glycolysis/ adenosine triphosphate synthesis and structural molecules. These changes can directly affect intercellular signaling and promote the hyperproliferation of epidermal cells. A better understanding of the metabolic effects of the proteomic changes observed could guide the development of new pharmacotherapies for psoriasis.</jats:p>