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Medientyp:
E-Artikel
Titel:
NSCLC as the Paradigm of Precision Medicine at Its Finest: The Rise of New Druggable Molecular Targets for Advanced Disease
Beteiligte:
Michelotti, Anna;
de Scordilli, Marco;
Bertoli, Elisa;
De Carlo, Elisa;
Del Conte, Alessandro;
Bearz, Alessandra
Erschienen:
MDPI AG, 2022
Erschienen in:
International Journal of Molecular Sciences, 23 (2022) 12, Seite 6748
Sprache:
Englisch
DOI:
10.3390/ijms23126748
ISSN:
1422-0067
Entstehung:
Anmerkungen:
Beschreibung:
Standard treatment for advanced non-small cell lung cancer (NSCLC) historically consisted of systemic cytotoxic chemotherapy until the early 2000s, when precision medicine led to a revolutionary change in the therapeutic scenario. The identification of oncogenic driver mutations in EGFR, ALK and ROS1 rearrangements identified a subset of patients who largely benefit from targeted agents. However, since the proportion of patients with druggable alterations represents a minority, the discovery of new potential driver mutations is still an urgent clinical need. We provide a comprehensive review of the emerging molecular targets in NSCLC and their applications in the advanced setting.