> Detailanzeige

Zuccalà, Paola; Latronico, Tiziana; Marocco, Raffaella; Savinelli, Stefano; Vita, Serena; Mengoni, Fabio; Tieghi, Tiziana; Borgo, Cosmo; Kertusha, Blerta; Carraro, Anna; D’Ettorre, Gabriella; Vullo, Vincenzo; Mastroianni, Claudio Maria; Liuzzi, Grazia Maria; Lichtner, Miriam

Longitudinal Assessment of Multiple Immunological and Inflammatory Parameters during Successful DAA Therapy in HCV Monoinfected and HIV/HCV Coinfected Subjects

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Longitudinal Assessment of Multiple Immunological and Inflammatory Parameters during Successful DAA Therapy in HCV Monoinfected and HIV/HCV Coinfected Subjects
  • Beteiligte: Zuccalà, Paola; Latronico, Tiziana; Marocco, Raffaella; Savinelli, Stefano; Vita, Serena; Mengoni, Fabio; Tieghi, Tiziana; Borgo, Cosmo; Kertusha, Blerta; Carraro, Anna; D’Ettorre, Gabriella; Vullo, Vincenzo; Mastroianni, Claudio Maria; Liuzzi, Grazia Maria; Lichtner, Miriam
  • Erschienen: MDPI AG, 2022
  • Erschienen in: International Journal of Molecular Sciences
  • Sprache: Englisch
  • DOI: 10.3390/ijms231911936
  • ISSN: 1422-0067
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>In the direct-acting antiviral (DAA) era, it is important to understand the immunological changes after HCV eradication in HCV monoinfected (mHCV) and in HIV/HCV coinfected (HIV/HCV) patients. In this study, we analyzed sub-populations of monocytes, dendritic cells (DCs), T-lymphocytes and inflammatory biomarkers following initiation of DAA in 15 mHCV and 16 HIV/HCV patients on effective antiretroviral therapy at baseline and after sustained virological response at 12 weeks (SVR12). Fifteen age- and sex-matched healthy donors (HD) were enrolled as a control group. Activated CD4+ and CD8+ T-lymphocytes, mDCs, pDCs, MDC8 and classical, non-classical and intermediate monocytes were detected using flow cytometry. IP-10, sCD163 and sCD14 were assessed by ELISA while matrix metalloproteinase-2 (MMP-2) was measured by zymography. At baseline, increased levels of IP-10, sCD163 and MMP-2 were found in both HIV/HCV and mHCV patients compared to HD, whereas sCD14 increased only in HIV/HCV patients. After therapy, IP-10, sCD163 and sCD14 decreased, whereas MMP-2 persistently elevated. At baseline, activated CD8+ T-cells were high in HIV/HCV and mHCV patients compared to HD, with a decrease at SVR12 only in HIV/HCV patients. Activated CD4+ T-cells were higher in HIV/HCV patients without modification after DAAs therapy. These results suggest complex interactions between both viruses and the immune system, which are only partially reversed by DAA treatment.</jats:p>
  • Zugangsstatus: Freier Zugang