Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
Medientyp:
E-Artikel
Titel:
COVID-19 Molecular Pathophysiology: Acetylation of Repurposing Drugs
Beteiligte:
Lee, Jong Hoon;
Kanwar, Badar;
Khattak, Asif;
Balentine, Jenny;
Nguyen, Ngoc Huy;
Kast, Richard E.;
Lee, Chul Joong;
Bourbeau, Jean;
Altschuler, Eric L.;
Sergi, Consolato M.;
Nguyen, Tuan Ngoc Minh;
Oh, Sangsuk;
Sohn, Mun-Gi;
Coleman, Michael
Erschienen:
MDPI AG, 2022
Erschienen in:International Journal of Molecular Sciences
Sprache:
Englisch
DOI:
10.3390/ijms232113260
ISSN:
1422-0067
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces immune-mediated type 1 interferon (IFN-1) production, the pathophysiology of which involves sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1) tetramerization and the cytosolic DNA sensor cyclic-GMP-AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling pathway. As a result, type I interferonopathies are exacerbated. Aspirin inhibits cGAS-mediated signaling through cGAS acetylation. Acetylation contributes to cGAS activity control and activates IFN-1 production and nuclear factor-κB (NF-κB) signaling via STING. Aspirin and dapsone inhibit the activation of both IFN-1 and NF-κB by targeting cGAS. We define these as anticatalytic mechanisms. It is necessary to alleviate the pathologic course and take the lag time of the odds of achieving viral clearance by day 7 to coordinate innate or adaptive immune cell reactions.</jats:p>