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Vică, Mihaela Laura; Dobreanu, Minodora; Curocichin, Ghenadie; Matei, Horea Vladi; Bâlici, Ștefana; Vușcan, Mihaela Elvira; Chiorean, Alin Dan; Nicula, Gheorghe Zsolt; Pavel Mironescu, Daniela Cristina; Leucuța, Daniel Corneliu; Teodoru, Cosmin Adrian; Siserman, Costel Vasile

The Influence of HLA Polymorphisms on the Severity of COVID-19 in the Romanian Population

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  • Medientyp: E-Artikel
  • Titel: The Influence of HLA Polymorphisms on the Severity of COVID-19 in the Romanian Population
  • Beteiligte: Vică, Mihaela Laura; Dobreanu, Minodora; Curocichin, Ghenadie; Matei, Horea Vladi; Bâlici, Ștefana; Vușcan, Mihaela Elvira; Chiorean, Alin Dan; Nicula, Gheorghe Zsolt; Pavel Mironescu, Daniela Cristina; Leucuța, Daniel Corneliu; Teodoru, Cosmin Adrian; Siserman, Costel Vasile
  • Erschienen: MDPI AG, 2024
  • Erschienen in: International Journal of Molecular Sciences
  • Sprache: Englisch
  • DOI: 10.3390/ijms25021326
  • ISSN: 1422-0067
  • Schlagwörter: Inorganic Chemistry ; Organic Chemistry ; Physical and Theoretical Chemistry ; Computer Science Applications ; Spectroscopy ; Molecular Biology ; General Medicine ; Catalysis
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>In this study, we aimed to investigate whether specific HLA alleles found in patients from Romania and the Republic of Moldova were associated with the severity of COVID-19 infection and its associated mortality. We analyzed the HLA alleles at the -A, -B, -C, -DRB1, and -DQB1 loci in a cohort of 130 individuals with severe and extremely severe forms of COVID-19, including 44 individuals who died. We compared these findings to a control group consisting of individuals who had either not been diagnosed with COVID-19 or had experienced mild forms of the disease. Using multivariate logistic regression models, we discovered that the B*27 and B*50 alleles were associated with an increased susceptibility to developing a severe form of COVID-19. The A*33 and C*15 alleles showed potential for offering protection against the disease. Furthermore, we identified two protective alleles (A*03 and DQB1*02) against the development of extremely severe forms of COVID-19. By utilizing score statistics, we established a statistically significant association between haplotypes and disease severity (p = 0.021). In summary, this study provides evidence that HLA genotype plays a role in influencing the clinical outcome of COVID-19 infection.</jats:p>
  • Zugangsstatus: Freier Zugang