Erschienen in:
Journal of Clinical Medicine, 12 (2023) 4, Seite 1463
Sprache:
Englisch
DOI:
10.3390/jcm12041463
ISSN:
2077-0383
Entstehung:
Anmerkungen:
Beschreibung:
With an incidence of 3–4.5 cases per million, adenoid cystic carcinoma (ACC) of the head and neck is one of the most common tumors of the parotid and sublingual salivary glands. In the clinical course, ACC is shown to have an aggressive long-term behavior, which leads to the fact that radical surgical resection of the tumor with tumor-free margins remains the “gold standard” in treating ACC. Particle radiation therapy and systemic molecular biological approaches offer new treatment options. However, risk factors for the formation and prognosis of ACC have not yet been clearly identified. The aim of the present review was to investigate long-term experience of diagnosis and treatment as well as risk and prognostic factors for occurrence and outcome of ACC.