Mendoza-Moreira, Angi Lizbeth;
Voigt, Anna Maria;
Stingl, Julia V.;
Rezapour, Jasmin;
Wagner, Felix Mathias;
Schuster, Alexander K.;
Hoffmann, Esther M.
Paul Glaucoma Implant following Congenital Cataract Surgery in a Pediatric Cohort
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Medientyp:
E-Artikel
Titel:
Paul Glaucoma Implant following Congenital Cataract Surgery in a Pediatric Cohort
Beteiligte:
Mendoza-Moreira, Angi Lizbeth;
Voigt, Anna Maria;
Stingl, Julia V.;
Rezapour, Jasmin;
Wagner, Felix Mathias;
Schuster, Alexander K.;
Hoffmann, Esther M.
Erschienen:
MDPI AG, 2024
Erschienen in:
Journal of Clinical Medicine, 13 (2024) 10, Seite 2914
Sprache:
Englisch
DOI:
10.3390/jcm13102914
ISSN:
2077-0383
Entstehung:
Anmerkungen:
Beschreibung:
Background: The aim of this study was to evaluate the short-term efficacy and safety of the Paul Glaucoma Implant (PGI) in pediatric eyes diagnosed with glaucoma following congenital cataract surgery (GFCS). Methods: A retrospective, single-center, descriptive study was conducted on consecutive children diagnosed with GFCS who underwent PGI implantation between July 2022 and November 2023 at the University Medical Center Mainz. The primary outcome measure was the reduction in IOP at the last follow-up visit. Results: Ten eyes of nine children were included in the study. The mean follow-up time was 7.70 ± 4.22 months (4.68–10.72 months). At the end of the study follow-up, the mean (95% CI) reduction in IOP was −14.8 ± 8.73 mmHg (−8.56 to −21.04 mmHg, p < 0.001). At the last follow-up, 30.0% (3/10) of patients achieved an IOP (intraocular pressure) of ≥6 and ≤21 mmHg with a reduction in IOP of ≥25% without treatment, while 90.0% (9/10) achieved this target IOP regardless of glaucoma medication treatment. The mean number of antiglaucoma medications was significantly reduced from 3.50 (IQR = 1) to 2.0 (IQR = 2, p = 0.01), and the visual acuity logMAR improved from 1.26 ± 0.62 to 1.03 ± 0.48 (p = 0.04). Only one eye experienced numerical hypotony (4 mmHg) without choroidal detachment or anterior chamber shallowing within the first 24 h. No other adverse events were observed during the follow-up period. Conclusions: PGI implantation significantly lowered IOP and the number of antiglaucoma eye drops with a favorable safety profile in children diagnosed with GFCS, thereby achieving a high rate of qualified surgical success in the short term.