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Medientyp:
E-Artikel
Titel:
HOX Protein Activity Regulation by Cellular Localization
Beteiligte:
Bridoux, Laure;
Gofflot, Françoise;
Rezsohazy, René
Erschienen:
MDPI AG, 2021
Erschienen in:Journal of Developmental Biology
Sprache:
Englisch
DOI:
10.3390/jdb9040056
ISSN:
2221-3759
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>While the functions of HOX genes have been and remain extensively studied in distinct model organisms from flies to mice, the molecular biology of HOX proteins remains poorly documented. In particular, the mechanisms involved in regulating the activity of HOX proteins have been poorly investigated. Nonetheless, based on data available from other well-characterized transcription factors, it can be assumed that HOX protein activity must be finely tuned in a cell-type-specific manner and in response to defined environmental cues. Indeed, records in protein–protein interaction databases or entries in post-translational modification registries clearly support that HOX proteins are the targets of multiple layers of regulation at the protein level. In this context, we review here what has been reported and what can be inferred about how the activities of HOX proteins are regulated by their intracellular distribution.</jats:p>