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Cameli, Paolo; Faverio, Paola; Ferrari, Katia; Bonti, Viola; Marsili, Stefania; Mazzei, Maria Antonietta; Mazzoni, Francesca; Bartolucci, Maurizio; Scotti, Vieri; Bertolini, Federica; Barbieri, Fausto; Baldessari, Cinzia; Veronese, Chiara; Boffi, Roberto; Brighenti, Matteo; Cortinovis, Diego; Dominici, Massimo; Pesci, Alberto; Bargagli, Elena; Luppi, Fabrizio

Immune-Checkpoint-Inhibitor-Related Lung Toxicity: A Multicentre Real-Life Retrospective Portrait from Six Italian Centres

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  • Medientyp: E-Artikel
  • Titel: Immune-Checkpoint-Inhibitor-Related Lung Toxicity: A Multicentre Real-Life Retrospective Portrait from Six Italian Centres
  • Beteiligte: Cameli, Paolo; Faverio, Paola; Ferrari, Katia; Bonti, Viola; Marsili, Stefania; Mazzei, Maria Antonietta; Mazzoni, Francesca; Bartolucci, Maurizio; Scotti, Vieri; Bertolini, Federica; Barbieri, Fausto; Baldessari, Cinzia; Veronese, Chiara; Boffi, Roberto; Brighenti, Matteo; Cortinovis, Diego; Dominici, Massimo; Pesci, Alberto; Bargagli, Elena; Luppi, Fabrizio
  • Erschienen: MDPI AG, 2022
  • Erschienen in: Life
  • Sprache: Englisch
  • DOI: 10.3390/life12081149
  • ISSN: 2075-1729
  • Schlagwörter: Paleontology ; Space and Planetary Science ; General Biochemistry, Genetics and Molecular Biology ; Ecology, Evolution, Behavior and Systematics
  • Entstehung:
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  • Beschreibung: <jats:p>Background: Immune checkpoint inhibitors (ICIs) have revolutionized the therapeutic horizons of various cancers. However, immune-related adverse events have been reported, including interstitial lung diseases. Our aim was to describe the clinical and radiological features and survival of a multicentre cohort of patients who developed ICI-related lung toxicity. Methods: Six Italian centres were involved in the study. Patients who were treated with anti-PD-1/PD-L1 and CTLA-4 mAbs and developed ICI-related lung toxicity were recruited retrospectively to study clinical, radiological, immunological and survival data. Results: A total of 41 patients (25 males, 66.8 ± 9.9 years) were enrolled. Lung toxicity occurred after 204.3 ± 208.3 days of therapy, with ground glass opacities being the most common HRCT pattern (23 cases). Male sex, lung cancer and acute respiratory failure were associated with a shorter latency of toxicity (p = 0.0030, p = 0.0245 and p = 0.0390, respectively). Patients who required high-flow oxygen therapy showed significantly worse survival (p = 0.0028). Conclusions: Our cohort showed heterogeneous clinical and radiological aspects of ICI-related lung toxicity, with a latency not limited to the first year of treatment. Severity was mainly mild to moderate, although life-threatening events did occur. Our data indicate that strict long-term follow-up is needed to enable early diagnosis and appropriate management.</jats:p>
  • Zugangsstatus: Freier Zugang